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    Dlx3 distal-less homeobox 3 [ Mus musculus (house mouse) ]

    Gene ID: 13393, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlx3provided by MGI
    Official Full Name
    distal-less homeobox 3provided by MGI
    Primary source
    MGI:MGI:94903
    See related
    Ensembl:ENSMUSG00000001510 AllianceGenome:MGI:94903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlx-3
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell surface receptor signaling pathway; epithelial cell differentiation; and hair follicle cell proliferation. Acts upstream of or within blood vessel development; odontogenesis of dentin-containing tooth; and placenta development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 4.7), stomach adult (RPKM 3.2) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dlx3 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95010943..95016122)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95120117..95125296)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene STARR-positive B cell enhancer ABC_E9839 Neighboring gene predicted gene, 53644 Neighboring gene integrin alpha 3 Neighboring gene predicted gene, 53645 Neighboring gene DNA damage-induced stem cell specific noncoding RNA Neighboring gene distal-less homeobox 4 Neighboring gene distal-less homeobox 4, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within odontoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in odontoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein DLX-3
    Names
    DII C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010055.4NP_034185.1  homeobox protein DLX-3

      See identical proteins and their annotated locations for NP_034185.1

      Status: VALIDATED

      Source sequence(s)
      AL606480
      Consensus CDS
      CCDS25272.1
      UniProtKB/Swiss-Prot
      Q64205
      UniProtKB/TrEMBL
      Q78ZZ8, Q9QWH3
      Related
      ENSMUSP00000090443.6, ENSMUST00000092768.7
      Conserved Domains (3) summary
      pfam00046
      Location:132185
      Homeobox; Homeobox domain
      pfam12413
      Location:27107
      DLL_N; Homeobox protein distal-less-like N terminal
      cl27820
      Location:109224
      Abdominal-A; Homeobox protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95010943..95016122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)