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    Isca1 iron-sulfur cluster assembly 1 [ Mus musculus (house mouse) ]

    Gene ID: 69046, updated on 27-Nov-2024

    Summary

    Official Symbol
    Isca1provided by MGI
    Official Full Name
    iron-sulfur cluster assembly 1provided by MGI
    Primary source
    MGI:MGI:1916296
    See related
    Ensembl:ENSMUSG00000044792 AllianceGenome:MGI:1916296
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbld2; 1810010A06Rik
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 131.8), liver E14.5 (RPKM 87.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Isca1 in Genome Data Viewer
    Location:
    13 B2; 13 31.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59903229..59917603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59755415..59769789, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528D03 gene Neighboring gene spermatogenesis associated 31 subfamily D, member 1E Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:59871197-59871469 Neighboring gene ethanol decreased 2 Neighboring gene terminal uridylyl transferase 7 Neighboring gene STARR-seq mESC enhancer starr_34725 Neighboring gene predicted gene, 19866

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    iron-sulfur cluster assembly 1 homolog, mitochondrial
    Names
    HESB like domain containing 2
    HESB-like domain-containing protein 2
    iron-sulfur assembly protein IscA
    NP_081197.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026921.4NP_081197.1  iron-sulfur cluster assembly 1 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081197.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134869
      Consensus CDS
      CCDS26578.1
      UniProtKB/Swiss-Prot
      Q5SZT5, Q9D924
      UniProtKB/TrEMBL
      I3ITR1
      Related
      ENSMUSP00000054858.7, ENSMUST00000057115.7
      Conserved Domains (1) summary
      TIGR00049
      Location:26129
      TIGR00049; Iron-sulfur cluster assembly accessory protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      59903229..59917603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)