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    Ift25 intraflagellar transport 25 [ Mus musculus (house mouse) ]

    Gene ID: 72938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ift25provided by MGI
    Official Full Name
    intraflagellar transport 25provided by MGI
    Primary source
    MGI:MGI:1920188
    See related
    Ensembl:ENSMUSG00000063172 AllianceGenome:MGI:1920188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP25; Hspb11; 2900042B11Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in kidney development; smoothened signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in embryo; germ cell of ovary; and secondary heart field. Orthologous to human IFT25 (intraflagellar transport 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 1.3), placenta adult (RPKM 1.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ift25 in Genome Data Viewer
    Location:
    4 C7; 4 50.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107110889..107137135)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107253593..107284497)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene Yip1 domain family, member 1 Neighboring gene deiodinase, iodothyronine, type I Neighboring gene replication factor C (activator 1) 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within intraciliary transport IC
    Inferred by Curator
    more info
    PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intraciliary transport particle B TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    intraflagellar transport protein 25 homolog
    Names
    heat shock protein beta-11
    heat shock protein family B (small), member 11
    placental protein 25 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355459.1NP_001342388.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA000737, AK013636, BB759869, BE863784
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000102360.2, ENSMUST00000106749.8
      Conserved Domains (1) summary
      cl23730
      Location:19121
      F5_F8_type_C; F5/8 type C domain
    2. NM_001355460.1NP_001342389.1  intraflagellar transport protein 25 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BB759869, BE863784
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000118617.2, ENSMUST00000152717.8
      Conserved Domains (1) summary
      cl23730
      Location:19121
      F5_F8_type_C; F5/8 type C domain
    3. NM_028394.3NP_082670.1  intraflagellar transport protein 25 homolog

      See identical proteins and their annotated locations for NP_082670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA000737, AA939607, BB759869, BY309412
      Consensus CDS
      CCDS18435.1
      UniProtKB/Swiss-Prot
      Q3TZR2, Q9D6H2
      Related
      ENSMUSP00000048810.8, ENSMUST00000046558.8
      Conserved Domains (1) summary
      cl23730
      Location:19121
      F5_F8_type_C; F5/8 type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107110889..107137135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320398.3XP_017175887.1  intraflagellar transport protein 25 homolog isoform X1

      UniProtKB/TrEMBL
      Q8VDG4
      Related
      ENSMUST00000156934.8