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    Dio1 deiodinase, iodothyronine, type I [ Mus musculus (house mouse) ]

    Gene ID: 13370, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dio1provided by MGI
    Official Full Name
    deiodinase, iodothyronine, type Iprovided by MGI
    Primary source
    MGI:MGI:94896
    See related
    Ensembl:ENSMUSG00000034785 AllianceGenome:MGI:94896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1; 5DI; ITDI1; TXDI1
    Summary
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in liver adult (RPKM 54.1), kidney adult (RPKM 25.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Dio1 in Genome Data Viewer
    Location:
    4 C7; 4 50.18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107148662..107164365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107291465..107307168, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene intraflagellar transport 25 Neighboring gene Yip1 domain family, member 1 Neighboring gene replication factor C (activator 1) 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11024 Neighboring gene STARR-positive B cell enhancer ABC_E10245 Neighboring gene NDC1 transmembrane nucleoporin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC107659

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables selenium binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyroxine 5'-deiodinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thyroxine 5'-deiodinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thyroxine 5'-deiodinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    type I iodothyronine deiodinase
    Names
    DIOI
    type 1 DI
    type-I 5'-deiodinase
    NP_031886.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007860.4NP_031886.3  type I iodothyronine deiodinase

      See identical proteins and their annotated locations for NP_031886.3

      Status: REVIEWED

      Source sequence(s)
      AL645723, BC089608
      Consensus CDS
      CCDS18436.1
      UniProtKB/Swiss-Prot
      Q05CY5, Q5FW63, Q61153
      UniProtKB/TrEMBL
      A0A0R4J110
      Related
      ENSMUSP00000081007.5, ENSMUST00000082426.11
      Conserved Domains (1) summary
      cl00388
      Location:8247
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107148662..107164365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)