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    Ccdc7a coiled-coil domain containing 7A [ Mus musculus (house mouse) ]

    Gene ID: 74703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc7aprovided by MGI
    Official Full Name
    coiled-coil domain containing 7Aprovided by MGI
    Primary source
    MGI:MGI:1921953
    See related
    Ensembl:ENSMUSG00000025808 AllianceGenome:MGI:1921953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Biot2; Ccdc7; Gm3952; 100042659; 4930517G15Rik; 4930540C21Rik
    Summary
    Orthologous to human CCDC7 (coiled-coil domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 9.4) See more
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    Genomic context

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    See Ccdc7a in Genome Data Viewer
    Location:
    8 E2; 8 76.12 cM
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (129460715..129791973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (128980019..129065492, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23105 Neighboring gene predicted gene, 26002 Neighboring gene integrin beta 1 (fibronectin receptor beta) Neighboring gene predicted gene, 26100 Neighboring gene STARR-seq mESC enhancer starr_23108 Neighboring gene STARR-positive B cell enhancer mm9_chr8:131465278-131465579 Neighboring gene predicted gene, 22545 Neighboring gene STARR-seq mESC enhancer starr_23110 Neighboring gene coiled-coil domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_23111 Neighboring gene STARR-seq mESC enhancer starr_23112 Neighboring gene STARR-seq mESC enhancer starr_23113 Neighboring gene predicted gene, 22374 Neighboring gene STARR-seq mESC enhancer starr_23114 Neighboring gene STARR-seq mESC enhancer starr_23115 Neighboring gene zinc finger protein 1006

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line. Zhou C, et al. Oncol Res, 2015. PMID 25706396, Free PMC Article
    2. [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development]. Wang H, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2009 Sep. PMID 19950598
    3. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Satoh A, et al. Cell Metab, 2013 Sep 3. PMID 24011076, Free PMC Article
    4. Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Satoh A, et al. Aging Cell, 2015 Apr. PMID 25546159, Free PMC Article
    5. RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells. Wang CT, et al. Cell Mol Biol Lett, 2009. PMID 19277478, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. silencing Biot2 in CT26 cells by RNA interference can inhibit cell growth in vitro and in vivo.
      Title: RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.
    2. Biot2-L was highly expressed in adult testis, and its expression increased regularly during testis development.
      Title: [Analysis of expression pattern of a novel testis-highly expressed gene Biot2-L and the primary study on its role in testis development].
    3. The Biot2 transcript was detected only and strongly in the testis tissues and abundantly in five types of murine cancer cell line.
      Title: RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Transgenic (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 7
    Names
    coiled-coil domain containing 7
    putative cancer/testis antigen
    testis-specific antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197041.1 → NP_001183970.1  coiled-coil domain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001183970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK015811, AK016006
      Consensus CDS
      CCDS57649.1
      UniProtKB/TrEMBL
      G3X9U4, Q9D4Y1
      Related
      ENSMUSP00000104379.3, ENSMUST00000108747.3
      Conserved Domains (1) summary
      pfam15368
      Location:1 → 148
      BioT2; Spermatogenesis family BioT2

    2. NM_001395237.1 → NP_001382166.1  coiled-coil domain-containing protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104928, AC148114, AC156608, AC159993
      UniProtKB/TrEMBL
      A0A1L1SS82
      Related
      ENSMUSP00000149790.2, ENSMUST00000214889.2
      Conserved Domains (2) summary
      COG1196
      Location:105 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1303 → 1659
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    3. NM_029061.3 → NP_083337.1  coiled-coil domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_083337.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
      Source sequence(s)
      AK015811, AK016006
      Consensus CDS
      CCDS40524.1
      UniProtKB/Swiss-Prot
      D3YY17, Q9D541
      UniProtKB/TrEMBL
      D3YVX2
      Related
      ENSMUSP00000092780.5, ENSMUST00000095158.11
      Conserved Domains (1) summary
      pfam15368
      Location:1 → 166
      BioT2; Spermatogenesis family BioT2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      129460715..129791973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D541.1 GenPept UniProtKB/Swiss-Prot:Q9D541

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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