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    Itga3 integrin alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 16400, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itga3provided by MGI
    Official Full Name
    integrin alpha 3provided by MGI
    Primary source
    MGI:MGI:96602
    See related
    Ensembl:ENSMUSG00000001507 AllianceGenome:MGI:96602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD49C; GAPB3
    Summary
    This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Broad expression in lung adult (RPKM 73.3), duodenum adult (RPKM 44.4) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itga3 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94935301..94967637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95044475..95076844, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene predicted gene 11513 Neighboring gene STARR-positive B cell enhancer ABC_E9839 Neighboring gene predicted gene, 53644 Neighboring gene predicted gene, 53645 Neighboring gene distal-less homeobox 3 Neighboring gene DNA damage-induced stem cell specific noncoding RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exploration behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nephron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal filtration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to gonadotropin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skin development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha3-beta1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alpha3-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin alpha-3
    Names
    CD49 antigen-like family member C
    VLA-3 receptor, alpha 3 subunit
    galactoprotein B3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306071.1NP_001293000.1  integrin alpha-3 isoform 2

      See identical proteins and their annotated locations for NP_001293000.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL606480, BC053031, BQ032311
      Consensus CDS
      CCDS83877.1
      UniProtKB/Swiss-Prot
      Q62470
      Related
      ENSMUSP00000103368.2, ENSMUST00000107739.8
      Conserved Domains (2) summary
      smart00191
      Location:337387
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:432887
      Integrin_alpha2; Integrin alpha
    2. NM_001306162.1NP_001293091.1  integrin alpha-3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001293091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon the 3' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC096741, CJ089026
      Consensus CDS
      CCDS83878.1
      UniProtKB/Swiss-Prot
      Q62470
      Related
      ENSMUSP00000113556.2, ENSMUST00000120375.8
      Conserved Domains (2) summary
      smart00191
      Location:368418
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:463918
      Integrin_alpha2; Integrin alpha
    3. NM_013565.3NP_038593.1  integrin alpha-3 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_038593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      BC053031, BQ032311
      Consensus CDS
      CCDS25271.1
      UniProtKB/Swiss-Prot
      Q08441, Q08442, Q5SWA8, Q5SWB9, Q62470, Q6P6I1
      Related
      ENSMUSP00000001548.8, ENSMUST00000001548.14
      Conserved Domains (2) summary
      smart00191
      Location:368418
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:463918
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94935301..94967637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532310.5XP_006532373.1  integrin alpha-3 isoform X1

      See identical proteins and their annotated locations for XP_006532373.1

      UniProtKB/Swiss-Prot
      Q62470
      Conserved Domains (2) summary
      smart00191
      Location:368418
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:463918
      Integrin_alpha2; Integrin alpha
    2. XM_006532311.5XP_006532374.1  integrin alpha-3 isoform X2

      See identical proteins and their annotated locations for XP_006532374.1

      UniProtKB/Swiss-Prot
      Q08441, Q08442, Q5SWA8, Q5SWB9, Q62470, Q6P6I1
      Conserved Domains (2) summary
      smart00191
      Location:368418
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:463918
      Integrin_alpha2; Integrin alpha