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    Synj2bp synaptojanin 2 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 24071, updated on 9-Dec-2024

    Summary

    Official Symbol
    Synj2bpprovided by MGI
    Official Full Name
    synaptojanin 2 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1344347
    See related
    Ensembl:ENSMUSG00000090935 AllianceGenome:MGI:1344347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARIP2; OMP25; ActRIP4; D12Wsu118e
    Summary
    Enables type II activin receptor binding activity. Involved in positive regulation of protein localization to cell surface; positive regulation of receptor internalization; and regulation of activin receptor signaling pathway. Acts upstream of or within Rho protein signal transduction; protein targeting; and regulation of endocytosis. Located in cell surface. Is expressed in several structures, including blood vessel; extraembryonic component; genitourinary system; neural tube; and retina. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.6), bladder adult (RPKM 3.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Synj2bp in Genome Data Viewer
    Location:
    12 D1; 12 37.73 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81538968..81579685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81492194..81532911, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene a disintegrin and metallopeptidase domain 4 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene mediator complex subunit 6 Neighboring gene 40S ribosomal protein S23 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type II activin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cytoplasm organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular distribution of mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptojanin-2-binding protein
    Names
    activin receptor interacting protein 2
    activin receptor-interacting protein 4
    mitochondrial outer membrane protein 25
    outer membrane protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309814.1NP_001296743.1  synaptojanin-2-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001296743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as ARIP2c) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY071903, AY566156, BY745220
      Consensus CDS
      CCDS83979.1
      UniProtKB/Swiss-Prot
      Q9D6K5
      Related
      ENSMUSP00000130691.2, ENSMUST00000169158.2
      Conserved Domains (1) summary
      cd00992
      Location:1397
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_025292.7NP_079568.1  synaptojanin-2-binding protein isoform 1

      See identical proteins and their annotated locations for NP_079568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC132391, AC154908, AI851233, AK163362, BY745220
      Consensus CDS
      CCDS26021.1
      UniProtKB/Swiss-Prot
      Q2TTN6, Q6YNE6, Q78HT9, Q8K4F3, Q9D6K5, Q9D8G4
      Related
      ENSMUSP00000129224.2, ENSMUST00000163402.8
      Conserved Domains (1) summary
      cd00992
      Location:1397
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. NR_132136.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC132391, AC154908, AI851233, AK030379, BY745220
    2. NR_132142.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AY071903, AY566156, BY745220

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81538968..81579685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)