U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 18604, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdk2provided by MGI
    Official Full Name
    pyruvate dehydrogenase kinase, isoenzyme 2provided by MGI
    Primary source
    MGI:MGI:1343087
    See related
    Ensembl:ENSMUSG00000038967 AllianceGenome:MGI:1343087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including insulin receptor signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; and regulation of gluconeogenesis. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Is expressed in aorta; cerebral cortex; cerebral cortex subventricular zone; heart; and liver. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 156.0), kidney adult (RPKM 138.3) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdk2 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94917084..94932197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95026258..95041371, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene predicted gene, 51875 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene predicted gene, 53200 Neighboring gene STARR-positive B cell enhancer ABC_E9839 Neighboring gene predicted gene 11513 Neighboring gene predicted gene, 53644 Neighboring gene integrin alpha 3 Neighboring gene predicted gene, 53645 Neighboring gene distal-less homeobox 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ketone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pyruvate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of pyruvate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pyruvate dehydrogenase kinase, isoenzyme 2
    Names
    PDH kinase 2
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
    pyruvate dehydrogenase 2
    pyruvate dehydrogenase kinase, isozyme 2
    NP_001348844.1
    NP_598428.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361915.1NP_001348844.1  pyruvate dehydrogenase kinase, isoenzyme 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI848783, BE647354, CK618575, CN538500, CX204954, CX208144
      Conserved Domains (2) summary
      cd16929
      Location:132297
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:1128
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
    2. NM_133667.2NP_598428.2  pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1

      See identical proteins and their annotated locations for NP_598428.2

      Status: VALIDATED

      Source sequence(s)
      AF267660, AI848783, CK618575, CX204954, CX223857
      Consensus CDS
      CCDS25270.1
      UniProtKB/Swiss-Prot
      Q8VC63, Q9JK42
      Related
      ENSMUSP00000041447.8, ENSMUST00000038431.8
      Conserved Domains (2) summary
      pfam10436
      Location:30192
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
      cd16929
      Location:196361
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94917084..94932197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)