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    CDK15 cyclin dependent kinase 15 [ Homo sapiens (human) ]

    Gene ID: 65061, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CDK15provided by HGNC
    Official Full Name
    cyclin dependent kinase 15provided by HGNC
    Primary source
    HGNC:HGNC:14434
    See related
    Ensembl:ENSG00000138395 MIM:616147; AllianceGenome:HGNC:14434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFTK2; ALS2CR7; PFTAIRE2
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK15 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201806429..201895550)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (202287333..202376437)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202671152..202760273)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 651, pseudogene Neighboring gene MAGUK p55 scaffold protein 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202563997-202564498 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202564499-202564998 Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16994 Neighboring gene ribosomal protein S2 pseudogene 16 Neighboring gene MPRA-validated peak4013 silencer Neighboring gene UBE2V1 pseudogene 11 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202766463-202767186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12237 Neighboring gene RNA, U6 small nuclear 440, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202813665-202814208 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202814209-202814750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827374-202827874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827875-202828375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16995 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:202835024-202835222 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202838433-202839337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202860883-202861447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202863716-202864219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202864220-202864722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202885061-202885586 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202887293-202888158 Neighboring gene Sharpr-MPRA regulatory region 624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202899462-202900302 Neighboring gene frizzled class receptor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway. Huang C, et al. Cell Death Differ, 2022 Jan. PMID 34262144, Free PMC Article
    2. Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer. Zhang X, et al. J Int Med Res, 2021 Jun. PMID 34162268, Free PMC Article
    3. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. Park MH, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24866247
    4. Mammalian cyclin-dependent kinases. Malumbres M, et al. Trends Biochem Sci, 2005 Nov. PMID 16236519
    5. Cyclin-dependent kinases: a family portrait. Malumbres M, et al. Nat Cell Biol, 2009 Nov. PMID 19884882, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating beta-catenin/ MEK-ERK signaling pathway.
      Title: CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
    2. Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer.
      Title: Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer.
    3. In summary, our results suggest that ALS2CR7 confers TRAIL resistance to cancer cells via phosphorylation of survivin.
      Title: ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 15
    Names
    PFTAIRE protein kinase 2
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein
    cell division protein kinase 15
    serine/threonine protein kinase
    serine/threonine-protein kinase ALS2CR7
    serine/threonine-protein kinase PFTAIRE-2
    NP_001248364.1
    NP_001248365.1
    NP_001353315.1
    NP_631897.1
    XP_011509952.1
    XP_011509954.1
    XP_011509956.1
    XP_011509957.1
    XP_011509958.1
    XP_011509959.1
    XP_047301508.1
    XP_047301509.1
    XP_054199420.1
    XP_054199421.1
    XP_054199422.1
    XP_054199423.1
    XP_054199424.1
    XP_054199425.1
    XP_054199426.1
    XP_054199427.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261435.1 → NP_001248364.1  cyclin-dependent kinase 15 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AC007242, AC007358, BX647394, DA050598
      Consensus CDS
      CCDS58747.1
      UniProtKB/Swiss-Prot
      Q96Q40
      Related
      ENSP00000406472.2, ENST00000450471.6
      Conserved Domains (2) summary
      PLN00009
      Location:103 → 390
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:102 → 387
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    2. NM_001261436.1 → NP_001248365.1  cyclin-dependent kinase 15 isoform 2

      See identical proteins and their annotated locations for NP_001248365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC038807, DA050598
      Consensus CDS
      CCDS58746.1
      UniProtKB/Swiss-Prot
      Q96Q40
      Related
      ENSP00000412775.1, ENST00000434439.1
      Conserved Domains (2) summary
      PLN00009
      Location:103 → 390
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:102 → 387
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    3. NM_001366386.2 → NP_001353315.1  cyclin-dependent kinase 15 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC007242, AC007358
      Consensus CDS
      CCDS92927.1
      UniProtKB/Swiss-Prot
      A8K8R9, B8ZZX0, C9J1N8, C9K003, F8W6H8, Q4ZG86, Q53TV1, Q6ZMR9, Q8IUP1, Q96Q40
      Related
      ENSP00000498608.2, ENST00000652192.3
      Conserved Domains (1) summary
      cd07870
      Location:102 → 387
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    4. NM_139158.2 → NP_631897.1  cyclin-dependent kinase 15 isoform 3

      See identical proteins and their annotated locations for NP_631897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate in-frame 5' exon and initiates translation at an upstream AUG compared to variant 1. This results in a shorter protein (isoform 3) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB053308, AC007242, AC007358
      Consensus CDS
      CCDS2350.1
      UniProtKB/Swiss-Prot
      Q96Q40
      Related
      ENSP00000260967.2, ENST00000260967.6
      Conserved Domains (2) summary
      PLN00009
      Location:52 → 339
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:51 → 336
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      201806429..201895550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511652.2 → XP_011509954.1  cyclin-dependent kinase 15 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:103 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:102 → 367
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011511650.3 → XP_011509952.1  cyclin-dependent kinase 15 isoform X1

      Conserved Domains (2) summary
      PLN00009
      Location:103 → 390
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:102 → 387
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    3. XM_047445552.1 → XP_047301508.1  cyclin-dependent kinase 15 isoform X3

    4. XM_011511654.3 → XP_011509956.1  cyclin-dependent kinase 15 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:102 → 338
      PKc_like; Protein Kinases, catalytic domain

    5. XM_047445553.1 → XP_047301509.1  cyclin-dependent kinase 15 isoform X5

    6. XM_011511656.3 → XP_011509958.1  cyclin-dependent kinase 15 isoform X6

      See identical proteins and their annotated locations for XP_011509958.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 207
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011511655.3 → XP_011509957.1  cyclin-dependent kinase 15 isoform X6

      See identical proteins and their annotated locations for XP_011509957.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 207
      PKc_like; Protein Kinases, catalytic domain

    8. XM_011511657.3 → XP_011509959.1  cyclin-dependent kinase 15 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:12 → 197
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_922991.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      202287333..202376437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343446.1 → XP_054199421.1  cyclin-dependent kinase 15 isoform X2

    2. XM_054343445.1 → XP_054199420.1  cyclin-dependent kinase 15 isoform X1

    3. XM_054343447.1 → XP_054199422.1  cyclin-dependent kinase 15 isoform X3

    4. XM_054343448.1 → XP_054199423.1  cyclin-dependent kinase 15 isoform X4

    5. XM_054343449.1 → XP_054199424.1  cyclin-dependent kinase 15 isoform X5

    6. XM_054343451.1 → XP_054199426.1  cyclin-dependent kinase 15 isoform X6

    7. XM_054343450.1 → XP_054199425.1  cyclin-dependent kinase 15 isoform X6

    8. XM_054343452.1 → XP_054199427.1  cyclin-dependent kinase 15 isoform X7

    RNA

    1. XR_008486494.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96Q40.2 GenPept UniProtKB/Swiss-Prot:Q96Q40

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