Vch chymase [Rattus norvegicus (Norway rat)] - Gene

Summary

Gene symbol: Vch
Gene description: chymase
See related: EnsemblRapid:ENSRNOG00000077062
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression: Biased expression in Thymus (RPKM 4.0), Lung (RPKM 1.6) and 3 other tissues See more
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Genomic context

Location:: 15p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33569741..33572295)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34862249..34864803)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

PMC208939P1 (e-PCR)
- UniSTS:271983

RH130188 (e-PCR)
- UniSTS:213475

General protein information

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Preferred Names: chymase

Names: vascular chymase

NP_058841.1

EC 3.4.21.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017145.2 → NP_058841.1 chymase precursor

See identical proteins and their annotated locations for NP_058841.1

Status: PROVISIONAL

Source sequence(s)

AF063851

UniProtKB/TrEMBL

O70500

Related

ENSRNOP00000046664.5, ENSRNOT00000043182.6

Conserved Domains (2) summary

smart00020
Location:20 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...