Slc25a11 solute carrier family 25 member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a11provided by RGD
Official Full Name: solute carrier family 25 member 11provided by RGD
Primary source: RGD:708476
See related: EnsemblRapid:ENSRNOG00000003815 AllianceGenome:RGD:708476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in several processes, including C4-dicarboxylate transport; gluconeogenesis; and inorganic anion transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1575.2), Muscle (RPKM 1266.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55856209..55859060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55357590..55360441, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57265903..57268018, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxoglutarate carrier works in a concerted manner to maintain the mitochondrial glutathione pool which is crucial for neuronal survival.
Title: Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport.
Bcl-2 and 2-oxoglutarate carrier appear to act in a coordinated manner to increase the mitochondrial glutathione pool and enhance resistance of cells to oxidative stress
Title: Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.
The oxoglutarate/malate carrier of rat brain mitochondria operates by a uniport exchange mechanism.
Title: The oxoglutarate/malate carrier of rat brain mitochondria operates by a uniport exchange mechanism.
the OGC is part of a mechanism of fuel-stimulated insulin secretion that is common to glucose, amino acid, and organic acid secretagogues, involving flux through the pyruvate/isocitrate cycling pathway
Title: The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.
porphyrin accumulation in mitochondria is mediated by OGC and porphyrins are able to competitively inhibit 2-oxoglutarate uptake into mitochondria
Title: Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.
data provide evidence for a role of the 2-oxoglutarate carrier as a glutathione transporting polypeptide
Title: Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137517 (e-PCR)
- UniSTS:219605

NoName (e-PCR)
- UniSTS:547034

Slc25a11 (e-PCR), detects polymorphism
- UniSTS:547034

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxoglutarate:malate antiporter activity	IEA Inferred from Electronic Annotation more info
enables oxoglutarate:malate antiporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in malate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in oxaloacetate(2-) transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial 2-oxoglutarate/malate carrier protein

Names: 2-oxoglutarate carrier; OGCP; alpha-oxoglutarate carrier; oxoglutarate carrier), member 11; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022398.3 → NP_071793.2 mitochondrial 2-oxoglutarate/malate carrier protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P97700

UniProtKB/TrEMBL

A6HG73, G3V6H5

Related

ENSRNOP00000005144.1, ENSRNOT00000005144.6

Conserved Domains (1) summary

pfam00153
Location:24 → 102

Mito_carr; Mitochondrial carrier protein