Hnmt histamine N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnmtprovided by RGD
Official Full Name: histamine N-methyltransferaseprovided by RGD
Primary source: RGD:71049
See related: EnsemblRapid:ENSRNOG00000005223 AllianceGenome:RGD:71049
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables histamine N-methyltransferase activity. Involved in several processes, including histamine metabolic process; response to cocaine; and response to interleukin-1. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be active in cytosol. Used to study brain infarction. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 723.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (26978274..27010291, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (6591804..6623821, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (905111..937038, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genomic structure of the rat and mouse histamine N-methyltransferase gene
Title: Genomic structure of the rat and mouse histamine N-methyltransferase gene.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histamine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histamine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables selenol Se-methyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in histamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in histamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in methylation	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor cell	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histamine N-methyltransferase

Names: HMT

NP_112306.1

EC 2.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.