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    Igkc immunoglobulin kappa constant [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igkcprovided by RGD
    Official Full Name
    immunoglobulin kappa constantprovided by RGD
    Primary source
    RGD:1562743
    See related
    AllianceGenome:RGD:1562743
    Gene type
    protein coding
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Igk@; D4Mit8
    Summary
    Predicted to be involved in adaptive immune response. Predicted to act upstream of or within B cell differentiation. Predicted to be part of IgG immunoglobulin complex. Orthologous to human IGKC (immunoglobulin kappa constant). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    4q31

    Bibliography

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    Related articles in PubMed

    1. Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment. Sanchez P, et al. Int Immunol, 1994 May. PMID 8080841
    2. Allelic forms of rat kappa chain genes: evidence for strong selection at the level of nucleotide sequence. Sheppard HW, et al. Proc Natl Acad Sci U S A, 1981 Nov. PMID 6273908, Free PMC Article
    3. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
    4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Other Names

    • immunoglobulin kappa chain

    Clone Names

    • MGC73014, MGC112745

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of IgG immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of alpha-beta T cell receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Names
    immunoglobulin kappa constant
    immunoglobulin kappa chain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01836.1 GenPept UniProtKB/Swiss-Prot:P01836

    Gene LinkOut

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