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    Serpina7 serpin family A member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpina7provided by RGD
    Official Full Name
    serpin family A member 7provided by RGD
    Primary source
    RGD:619833
    See related
    EnsemblRapid:ENSRNOG00000011081 AllianceGenome:RGD:619833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tbg
    Summary
    Enables hormone binding activity. Involved in several processes, including response to corticosterone; response to prostaglandin E; and response to vitamin A. Located in extracellular space. Biomarker of hyperthyroidism and hypothyroidism. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 213.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serpina7 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107452044..107510958, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (102663242..102722319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (110226565..110232202, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily E member 1, pseudogene 1 Neighboring gene UBX domain protein 2A, pseudogene 1 Neighboring gene glutamic acid-rich protein-like Neighboring gene uncharacterized LOC108349242 Neighboring gene PWWP domain containing 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of vitamin A deficiency on thyroid function and serum thyroxine levels in the rat. Oba K, et al. J Nutr Sci Vitaminol (Tokyo), 1980. PMID 6785400
    2. Goiter formation following prostaglandin administration in rats. Lupulescu A. Am J Pathol, 1976 Oct. PMID 970439, Free PMC Article
    3. Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition. Rouaze-Romet M, et al. Acta Endocrinol (Copenh), 1992 Nov. PMID 1471456
    4. Structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. Rouaze-Romet M, et al. Biochem J, 1992 Aug 15. PMID 1520259, Free PMC Article
    5. Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. Tahirović H, et al. Acta Paediatr Hung, 1991. PMID 1867879

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thyroid hormone transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-embryonic development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to prostaglandin E IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to vitamin A IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyroxine-binding globulin
    Names
    T4-binding globulin
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
    serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
    serpin A7
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031128.1 → NP_112390.1  thyroxine-binding globulin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P35577
      UniProtKB/TrEMBL
      A0A140TAB0, A6KNW8
      Related
      ENSRNOP00000014739.5, ENSRNOT00000014739.8
      Conserved Domains (1) summary
      cd19555
      Location:48 → 425
      serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      107452044..107510958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100095.2 → XP_038956023.1  thyroxine-binding globulin isoform X7

      Conserved Domains (1) summary
      cl38926
      Location:1 → 217
      serpin; SERine Proteinase INhibitors (serpin) family

    2. XM_039100093.2 → XP_038956021.1  thyroxine-binding globulin isoform X6

      Conserved Domains (1) summary
      cl38926
      Location:48 → 218
      serpin; SERine Proteinase INhibitors (serpin) family

    3. XM_039100092.2 → XP_038956020.1  thyroxine-binding globulin isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q6F2
      Related
      ENSRNOP00000076228.2, ENSRNOT00000093401.3
      Conserved Domains (1) summary
      cl38926
      Location:4 → 248
      serpin; SERine Proteinase INhibitors (serpin) family

    4. XM_039100091.2 → XP_038956019.1  thyroxine-binding globulin isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q6F2
      Conserved Domains (1) summary
      cl38926
      Location:4 → 258
      serpin; SERine Proteinase INhibitors (serpin) family

    5. XM_063280328.1 → XP_063136398.1  thyroxine-binding globulin isoform X1

      UniProtKB/Swiss-Prot
      P35577
      UniProtKB/TrEMBL
      A6KNW8

    6. XM_063280329.1 → XP_063136399.1  thyroxine-binding globulin isoform X4

    7. XM_063280330.1 → XP_063136400.1  thyroxine-binding globulin isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35577.2 GenPept UniProtKB/Swiss-Prot:P35577

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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