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    kcnj16.S potassium inwardly rectifying channel subfamily J member 16 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373785, updated on 4-Jan-2025

    Summary

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    Official Symbol
    kcnj16.S
    Official Full Name
    potassium inwardly rectifying channel subfamily J member 16 S homeolog
    Primary source
    Xenbase:XB-GENE-987682
    Locus tag
    XELAEV_18046397mg
    See related
    EnsemblRapid:ENSXLAG00005030498 AllianceGenome:Xenbase:XB-GENE-987682
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    Kir5.1; kcnj16; kcnj16-A
    Summary
    Predicted to enable inward rectifier potassium channel activity. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See kcnj16.S in Genome Data Viewer
    Location:
    chromosome: 9_10S
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (18611730..18652569)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (17847659..17888437)

    Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene targeting protein for Xklp2-B-like Neighboring gene MAP kinase activator XMEK3 Neighboring gene potassium inwardly rectifying channel subfamily J member 2 S homeolog Neighboring gene uncharacterized XB5729910 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel. Rojas A, et al. Biochim Biophys Acta, 2007 Sep. PMID 17585871, Free PMC Article
    2. Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. Casamassima M, et al. J Biol Chem, 2003 Oct 31. PMID 12923169
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results suggest that the Kir4.1-Kir5.1 but not the homomeric Kir4.1 channel is strongly inhibited by PKC activation.
      Title: Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.
    2. Kir4.1 and Kir5.1 potassium channels bind with a heteromeric interaction that influences rectification, gating, and pH sensitivity
      Title: Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inward rectifier potassium channel 16
    Names
    potassium channel, inwardly rectifying subfamily J, member 16 S homeolog
    potassium inwardly-rectifying channel, subfamily J, member 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085718.1 → NP_001079187.1  inward rectifier potassium channel 16

      See identical proteins and their annotated locations for NP_001079187.1

      Status: PROVISIONAL

      Source sequence(s)
      BC042221
      UniProtKB/TrEMBL
      Q8AVK5
      Related
      ENSXLAP00005091282.1, ENSXLAT00005092962.1
      Conserved Domains (1) summary
      pfam01007
      Location:34 → 341
      IRK; Inward rectifier potassium channel

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      18611730..18652569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018237159.2 → XP_018092648.1  inward rectifier potassium channel 16 isoform X1

      UniProtKB/TrEMBL
      A0A1L8EM60, A0A974H0K0
      Related
      ENSXLAP00005091302.1, ENSXLAT00005092983.1
      Conserved Domains (2) summary
      pfam01007
      Location:35 → 170
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 342
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_018237158.2 → XP_018092647.1  inward rectifier potassium channel 16 isoform X1

      UniProtKB/TrEMBL
      A0A1L8EM60, A0A974H0K0
      Related
      ENSXLAP00005091325.1, ENSXLAT00005093005.1
      Conserved Domains (2) summary
      pfam01007
      Location:35 → 170
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 342
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. XM_018237161.2 → XP_018092650.1  inward rectifier potassium channel 16 isoform X1

      UniProtKB/TrEMBL
      A0A1L8EM60, A0A974H0K0
      Related
      ENSXLAP00005091367.1, ENSXLAT00005093047.1
      Conserved Domains (2) summary
      pfam01007
      Location:35 → 170
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 342
      IRK_C; Inward rectifier potassium channel C-terminal domain

    4. XM_018237162.2 → XP_018092651.1  inward rectifier potassium channel 16 isoform X1

      UniProtKB/TrEMBL
      A0A1L8EM60, A0A974H0K0
      Related
      ENSXLAP00005091347.1, ENSXLAT00005093027.1
      Conserved Domains (2) summary
      pfam01007
      Location:35 → 170
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 342
      IRK_C; Inward rectifier potassium channel C-terminal domain

    5. XM_041577614.1 → XP_041433548.1  inward rectifier potassium channel 16 isoform X1

      UniProtKB/TrEMBL
      A0A1L8EM60, A0A974H0K0
      Related
      ENSXLAP00005091237.1, ENSXLAT00005092917.1
      Conserved Domains (2) summary
      pfam01007
      Location:35 → 170
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:179 → 342
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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