Usp14 ubiquitin specific peptidase 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp14provided by MGI
Official Full Name: ubiquitin specific peptidase 14provided by MGI
Primary source: MGI:MGI:1928898
See related: Ensembl:ENSMUSG00000047879 AllianceGenome:MGI:1928898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ax; nmf375; 2610005K12Rik; 2610037B11Rik
Summary: Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 14.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.91 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (9993615..10030149, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (9993615..10030149, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro.
Title: Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro.
Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in Parkinson's disease.
Title: Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson's disease.
Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.
Title: Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.
USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice.
Title: USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice.
USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
Title: USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
Title: USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
Title: Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization.
Title: USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization.
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.
Title: USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Title: Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Gene trapped (1)
Spontaneous (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126430 (e-PCR)
- UniSTS:163138

AW107924 (e-PCR)
- UniSTS:181082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IEA Inferred from Electronic Annotation more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic cytosol	NAS Non-traceable Author Statement more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 14

Names: ataxia; dUB-type TGT for deubiquitinating enzyme; deubiquitinating enzyme 14; ubiquitin specific protease 14; ubiquitin thioesterase 14; ubiquitin thiolesterase 14; ubiquitin-specific-processing protease 14

NP_001033678.1

EC 3.4.19.12

NP_001347813.1

EC 3.4.19.12

NP_067497.2

EC 3.4.19.12

XP_006526197.1

EC 3.4.19.12

XP_030106415.1

EC 3.4.19.12

XP_030106416.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038589.2 → NP_001033678.1 ubiquitin carboxyl-terminal hydrolase 14 isoform 2

Status: VALIDATED

Source sequence(s)

AC163451, CB520876, CJ161902, CK621440, CN531861

Consensus CDS

CCDS37734.1

UniProtKB/TrEMBL

E9PYI8, Q80UN0

Related

ENSMUSP00000112368.2, ENSMUST00000116669.2

Conserved Domains (3) summary

cd02657
Location:71 → 445

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

pfam00443
Location:69 → 444

UCH; Ubiquitin carboxyl-terminal hydrolase

cl00155
Location:5 → 64

UBQ; Ubiquitin-like proteins
NM_001360884.1 → NP_001347813.1 ubiquitin carboxyl-terminal hydrolase 14 isoform 3

Status: VALIDATED

Source sequence(s)

AC163451

UniProtKB/TrEMBL

Q80UN0

Conserved Domains (2) summary

cd02657
Location:45 → 419

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

cl28922
Location:1 → 39

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
NM_021522.4 → NP_067497.2 ubiquitin carboxyl-terminal hydrolase 14 isoform 1

See identical proteins and their annotated locations for NP_067497.2

Status: VALIDATED

Source sequence(s)

AC163451, AK011322, AK029977, CJ161902

Consensus CDS

CCDS37735.1

UniProtKB/Swiss-Prot

Q543U5, Q923F2, Q9D0L0, Q9JMA1

UniProtKB/TrEMBL

Q80UN0

Related

ENSMUSP00000089728.7, ENSMUST00000092096.14

Conserved Domains (4) summary

smart00213
Location:5 → 74

UBQ; Ubiquitin homologues

cd02657
Location:106 → 480

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

pfam00443
Location:104 → 479

UCH; Ubiquitin carboxyl-terminal hydrolase

cl00155
Location:5 → 74

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

9993615..10030149 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250556.2 → XP_030106416.1 ubiquitin carboxyl-terminal hydrolase 14 isoform X2

UniProtKB/TrEMBL

Q80UN0

Conserved Domains (2) summary

cd02657
Location:45 → 419

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

cl28922
Location:1 → 39

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030250555.1 → XP_030106415.1 ubiquitin carboxyl-terminal hydrolase 14 isoform X1

UniProtKB/TrEMBL

Q80UN0

Conserved Domains (2) summary

cd02657
Location:80 → 454

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

cd16104
Location:1 → 50

Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
XM_006526134.5 → XP_006526197.1 ubiquitin carboxyl-terminal hydrolase 14 isoform X1

UniProtKB/TrEMBL

Q80UN0

Conserved Domains (2) summary

cd02657
Location:80 → 454

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

cd16104
Location:1 → 50

Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins