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    Tcea1 transcription elongation factor A (SII) 1 [ Mus musculus (house mouse) ]

    Gene ID: 21399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcea1provided by MGI
    Official Full Name
    transcription elongation factor A (SII) 1provided by MGI
    Primary source
    MGI:MGI:1196624
    See related
    Ensembl:ENSMUSG00000033813 AllianceGenome:MGI:1196624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S-II
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Acts upstream of or within erythrocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lung; and spleen. Orthologous to human TCEA1 (transcription elongation factor A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 29.3), liver E14 (RPKM 24.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcea1 in Genome Data Viewer
    Location:
    1 A1; 1 1.79 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4927917..4968132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4857694..4897909)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lysophospholipase 1 Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00045 Neighboring gene regulator of G-protein signaling 20 Neighboring gene STARR-seq mESC enhancer starr_00046 Neighboring gene STARR-seq mESC enhancer starr_00048 Neighboring gene predicted gene 16041 Neighboring gene STARR-seq mESC enhancer starr_00049 Neighboring gene STARR-seq mESC enhancer starr_00050 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence. Siametis A, et al. Nat Commun, 2024 May 14. PMID 38744897, Free PMC Article
    2. TCEA1 regulates the proliferative potential of mouse myeloid cells. Yang T, et al. Exp Cell Res, 2018 Sep 15. PMID 30009791, Free PMC Article
    3. Molecular cloning of cDNA and tissue-specific expression of the gene for SII-K1, a novel transcription elongation factor SII. Taira Y, et al. Genes Cells, 1998 May. PMID 9685180
    4. Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. Hirashima S, et al. J Biol Chem, 1988 Mar 15. PMID 3346229
    5. Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Park KS, et al. Stem Cells, 2013 Feb. PMID 23169579, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103154

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein 1
    Names
    transcription elongation factor S-II protein 1
    transcription elongation factor TFIIS.o

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159750.1 → NP_001153222.1  transcription elongation factor A protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal aa compared to isoform 1.
      Source sequence(s)
      AK136035, BC083127, CD545750, CJ059479
      UniProtKB/TrEMBL
      Q3UPE0
      Conserved Domains (1) summary
      cl02637
      Location:4 → 300
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    2. NM_001159751.1 → NP_001153223.1  transcription elongation factor A protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK131928, AK136035, BC083127
      Consensus CDS
      CCDS48212.1
      UniProtKB/TrEMBL
      E9PYD5, Q3UPE0
      Related
      ENSMUSP00000129157.3, ENSMUST00000165720.3
      Conserved Domains (4) summary
      cd00183
      Location:35 → 89
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:265 → 311
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:33 → 312
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:149 → 256
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    3. NM_011541.4 → NP_035671.1  transcription elongation factor A protein 1 isoform 2

      See identical proteins and their annotated locations for NP_035671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK136035, BC083127, CJ059479
      Consensus CDS
      CCDS35505.1
      UniProtKB/Swiss-Prot
      P10711, P10712, P23713
      UniProtKB/TrEMBL
      Q3UPE0, Q3UWX7
      Related
      ENSMUSP00000080266.8, ENSMUST00000081551.14
      Conserved Domains (1) summary
      cl02637
      Location:4 → 301
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4927917..4968132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10711.2 GenPept UniProtKB/Swiss-Prot:P10711

    Gene LinkOut

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