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    Ren renin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24715, updated on 27-Nov-2024

    Summary

    Official Symbol
    Renprovided by RGD
    Official Full Name
    reninprovided by RGD
    Primary source
    RGD:3554
    See related
    EnsemblRapid:ENSRNOG00000002937 AllianceGenome:RGD:3554
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ren1; RENAA; RATRENAA
    Summary
    Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cAMP; and response to cGMP. Located in extracellular space. Used to study hypertension. Biomarker of hypertension and primary biliary cholangitis. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 164.4) See more
    Orthologs
    NEW
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    Genomic context

    See Ren in Genome Data Viewer
    Location:
    13q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47348312..47359539)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (44796260..44807491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50502724..50513953, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene golgi transport 1A Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene uncharacterized LOC102550525 Neighboring gene ethanolamine kinase 2 Neighboring gene SRY-box transcription factor 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in angiotensin maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiotensin maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within angiotensin maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiotensin maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within establishment of blood-nerve barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in juxtaglomerular apparatus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesonephros development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood volume by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cGMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    renin
    Names
    angiotensinogenase
    renin 1 structural
    NP_036774.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012642.4NP_036774.4  renin precursor

      See identical proteins and their annotated locations for NP_036774.4

      Status: PROVISIONAL

      Source sequence(s)
      BC078878
      UniProtKB/Swiss-Prot
      P08424, Q63497
      UniProtKB/TrEMBL
      A6IC75, A6IC76
      Related
      ENSRNOP00000003951.2, ENSRNOT00000003951.6
      Conserved Domains (2) summary
      cd05487
      Location:76401
      renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
      pfam07966
      Location:3164
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      47348312..47359539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)