Nptx2 neuronal pentraxin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nptx2provided by RGD
Official Full Name: neuronal pentraxin 2provided by RGD
Primary source: RGD:1309447
See related: EnsemblRapid:ENSRNOG00000001006 AllianceGenome:RGD:1309447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NP2; Narp; NP-II
Summary: Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse and synaptic cleft. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human NPTX2 (neuronal pentraxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 101.2), Testes (RPKM 89.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15151136..15162045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10037435..10048345, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12014638..12025547, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding.
Title: HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding.
Narp expression is stimulated by naturally occurring vestibular input. Narp may mediate ongoing adjustments in synaptic strength or connectivity in several pathways linked to the vestibular system.
Title: Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablation.
This study suggested that mPFC Narp is necessary for extinction of opiate seeking in the Pavlovian-conditioned place preference paradigm but not in the operant paradigm of drug self-administration.
Title: Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.
Downregulation of GluR2 subunit in the inferior colliculus may contribute to audiogenic seizure mediated epileptogenesis, while upregulation of Narp may also be involved.
Title: AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior colliculus of P77PMC rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142204 (e-PCR)
- UniSTS:231454

AU049050 (e-PCR)
- UniSTS:145498

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in associative learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extrinsic component of postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: neuronal pentraxin-2

Names: Neuronal activity regulated pentraxin; neuro activity regulated petaxin; neuronal activity-regulated pentraxin; neuronal pentraxin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034199.1 → NP_001029371.1 neuronal pentraxin-2 precursor

Status: VALIDATED

Source sequence(s)

CB578587, CO388671, CO395871, CO403402

UniProtKB/Swiss-Prot

P97738

UniProtKB/TrEMBL

F1LR84

Related

ENSRNOP00000001331.3, ENSRNOT00000001331.6

Conserved Domains (2) summary

smart00159
Location:220 → 425

PTX; Pentraxin / C-reactive protein / pentaxin family

PRK02224
Location:58 → 174

PRK02224; DNA double-strand break repair Rad50 ATPase