Traf7 TNF receptor-associated factor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf7provided by MGI
Official Full Name: TNF receptor-associated factor 7provided by MGI
Primary source: MGI:MGI:3042141
See related: Ensembl:ENSMUSG00000052752 AllianceGenome:MGI:3042141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RFWD1
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including cellular response to interleukin-6; negative regulation of transcription by RNA polymerase II; and positive regulation of protein sumoylation. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in genitourinary system and pancreas epithelium. Human ortholog(s) of this gene implicated in adenomatoid tumor; hepatocellular carcinoma; and peritoneal mesothelioma. Orthologous to human TRAF7 (TNF receptor associated factor 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 69.0), lung adult (RPKM 60.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.4 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24727824..24746912, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24508850..24527938, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor.
Title: The seventh ring: exploring TRAF7 functions.
These results suggest a new mechanism by which MyoD1 function is coupled to NF-kappaB activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis.
Title: Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis.
TRAF7 negatively regulates c-Myb activity by sequestering c-Myb to the cytosol via sumoylation.
Title: TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-6	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRAF7

Names: RING-type E3 ubiquitin transferase TRAF7; ring finger and WD repeat domain 1

NP_001165584.1

EC 2.3.2.27

NP_001165585.1

EC 2.3.2.27

NP_001402080.1

EC 2.3.2.27

NP_722487.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172113.2 → NP_001165584.1 E3 ubiquitin-protein ligase TRAF7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC132367

Consensus CDS

CCDS50014.1

UniProtKB/Swiss-Prot

Q922B6, Q99JV3

UniProtKB/TrEMBL

F8WJF7

Related

ENSMUSP00000134759.2, ENSMUST00000176652.8

Conserved Domains (6) summary

cl17044
Location:281 → 321

DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I

smart00184
Location:130 → 162

RING; Ring finger

COG2319
Location:379 → 667

WD40; WD40 repeat [General function prediction only]

cd00200
Location:387 → 667

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:442 → 476

7WD40; WD40 repeat [structural motif]

cl19105
Location:206 → 279

Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
NM_001172114.2 → NP_001165585.1 E3 ubiquitin-protein ligase TRAF7 isoform 2

See identical proteins and their annotated locations for NP_001165585.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC132367

Consensus CDS

CCDS50015.1

UniProtKB/Swiss-Prot

Q922B6, Q99JV3

UniProtKB/TrEMBL

Q8C2K8

Related

ENSMUSP00000135267.2, ENSMUST00000176353.8

Conserved Domains (6) summary

cl17044
Location:241 → 281

DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I

smart00184
Location:92 → 124

RING; Ring finger

COG2319
Location:339 → 627

WD40; WD40 repeat [General function prediction only]

cd00200
Location:347 → 627

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:402 → 436

7WD40; WD40 repeat [structural motif]

cl19105
Location:168 → 239

Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
NM_001415151.1 → NP_001402080.1 E3 ubiquitin-protein ligase TRAF7 isoform 3

Status: VALIDATED

Source sequence(s)

AC132367
NM_153792.2 → NP_722487.2 E3 ubiquitin-protein ligase TRAF7 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site and a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC132367

UniProtKB/Swiss-Prot

Q922B6, Q99JV3

Conserved Domains (6) summary

cl17044
Location:254 → 294

DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I

smart00184
Location:103 → 135

RING; Ring finger

COG2319
Location:352 → 640

WD40; WD40 repeat [General function prediction only]

cd00200
Location:360 → 640

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:415 → 449

7WD40; WD40 repeat [structural motif]

cl19105
Location:179 → 252

Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...