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    Nipal3 NIPA-like domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 74552, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nipal3provided by MGI
    Official Full Name
    NIPA-like domain containing 3provided by MGI
    Primary source
    MGI:MGI:1921802
    See related
    Ensembl:ENSMUSG00000028803 AllianceGenome:MGI:1921802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npal3; 9130020G22Rik
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; central nervous system; ganglia; genitourinary system; and nasal cavity epithelium. Orthologous to human NIPAL3 (NIPA like domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 17.0), colon adult (RPKM 13.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nipal3 in Genome Data Viewer
    Location:
    4 D3; 4 67.64 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135173454..135222283, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135442805..135494972, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene noncompact myelin associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene STARR-seq mESC enhancer starr_11721 Neighboring gene sperm tail PG rich repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_11724 Neighboring gene grainyhead like transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E6235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135126769-135126952 Neighboring gene STARR-seq mESC enhancer starr_11727 Neighboring gene predicted gene, 30888 Neighboring gene STARR-seq mESC enhancer starr_11728 Neighboring gene STARR-seq mESC enhancer starr_11730 Neighboring gene RIKEN cDNA 1700029M20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Grzmil P, et al. Cytogenet Genome Res, 2009. PMID 19738379
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NIPA-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347220.1 → NP_001334149.1  NIPA-like protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL627185, AL670720
      Consensus CDS
      CCDS84805.1
      UniProtKB/TrEMBL
      A2A987
      Related
      ENSMUSP00000101482.3, ENSMUST00000105856.9
      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    2. NM_001361484.1 → NP_001348413.1  NIPA-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627185, AL670720
      Consensus CDS
      CCDS18786.1
      UniProtKB/Swiss-Prot
      Q6PG85, Q8BGN5, Q9D2Y2
      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    3. NM_028995.4 → NP_083271.1  NIPA-like protein 3 isoform 2

      See identical proteins and their annotated locations for NP_083271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK138843, BY245070, CD774340
      Consensus CDS
      CCDS18786.1
      UniProtKB/Swiss-Prot
      Q6PG85, Q8BGN5, Q9D2Y2
      Related
      ENSMUSP00000099608.4, ENSMUST00000102549.10
      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135173454..135222283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539230.5 → XP_006539293.1  NIPA-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006539293.1

      UniProtKB/TrEMBL
      A2A987
      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    2. XM_030253855.2 → XP_030109715.1  NIPA-like protein 3 isoform X4

      Conserved Domains (1) summary
      cl23754
      Location:4 → 165
      EamA; EamA-like transporter family

    3. XM_030253854.1 → XP_030109714.1  NIPA-like protein 3 isoform X3

      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    4. XM_036164503.1 → XP_036020396.1  NIPA-like protein 3 isoform X5

      Conserved Domains (1) summary
      cl23754
      Location:10 → 165
      EamA; EamA-like transporter family

    5. XM_006539231.2 → XP_006539294.1  NIPA-like protein 3 isoform X3

      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    6. XM_036164502.1 → XP_036020395.1  NIPA-like protein 3 isoform X2

      Conserved Domains (1) summary
      cl23754
      Location:36 → 330
      EamA; EamA-like transporter family

    RNA

    1. XR_003955032.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGN5.1 GenPept UniProtKB/Swiss-Prot:Q8BGN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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