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    Prps2 phosphoribosyl pyrophosphate synthetase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24689, updated on 9-Dec-2024

    Summary

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    Symbol
    Prps2provided by RGD
    Full Name
    phosphoribosyl pyrophosphate synthetase 2provided by RGD
    Primary source
    RGD:3415
    See related
    EnsemblRapid:ENSRNOG00000004160 AllianceGenome:RGD:3415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 165.1), Thymus (RPKM 152.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prps2 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (30592845..30630127)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (26975915..27013184)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (28435275..28472882)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC686042 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA70 Neighboring gene toll-like receptor 7 Neighboring gene Y box binding protein 1, pseudogene 7 Neighboring gene toll-like receptor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Complete cDNA sequence of rat phosphoribosylpyrophosphate synthetase subunit II (PRS II). Ishijima S, et al. Nucleic Acids Res, 1989 Nov 11. PMID 2555778, Free PMC Article
    2. Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Sonoda T, et al. Biochim Biophys Acta, 1998 Sep 8. PMID 9748490
    3. Kinetic and regulatory properties of rat liver phosphoribosylpyrophosphate synthetase complex are partly distinct from those of isolated recombinant component catalytic subunits. Sonoda T, et al. J Biochem, 1997 Sep. PMID 9348095
    4. Nucleotide and deduced amino acid sequences of two distinct cDNAs for rat phosphoribosylpyrophosphate synthetase. Taira M, et al. J Biol Chem, 1987 Nov 5. PMID 2822704
    5. Expression of rat phosphoribosylpyrophosphate synthetase subunits I and II in Escherichia coli. Isolation and characterization of the recombinant isoforms. Ishijima S, et al. J Biol Chem, 1991 Aug 25. PMID 1651917

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose phosphate diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose phosphate diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose phosphate diphosphokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribose phosphate diphosphokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribose phosphate diphosphokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribose-phosphate pyrophosphokinase 2
    Names
    PRS-II
    Phophoribosylpyrophosphate synthetase, subunit II
    phosphoribosyl pyrophosphate synthase II
    phosphoribosyl pyrophosphate synthetase II
    ribose-phosphate pyrophosphokinase 2-like
    NP_036766.1
    XP_006256891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012634.2 → NP_036766.1  ribose-phosphate pyrophosphokinase 2

      See identical proteins and their annotated locations for NP_036766.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P09330, Q63462
      UniProtKB/TrEMBL
      A0A8L2R3X1, A6K2F9
      Conserved Domains (1) summary
      COG0462
      Location:1 → 313
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      30592845..30630127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256829.5 → XP_006256891.1  ribose-phosphate pyrophosphokinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006256891.1

      UniProtKB/TrEMBL
      A0A8L2Q1L2, A0A8L2R3X1
      Related
      ENSRNOP00000005615.2, ENSRNOT00000005615.5
      Conserved Domains (1) summary
      COG0462
      Location:1 → 316
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09330.3 GenPept UniProtKB/Swiss-Prot:P09330

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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