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    Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 [ Mus musculus (house mouse) ]

    Gene ID: 66218, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ndufb9provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B9provided by MGI
    Primary source
    MGI:MGI:1913468
    See related
    Ensembl:ENSMUSG00000022354 AllianceGenome:MGI:1913468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-B22; 1190008J14Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 24. Orthologous to human NDUFB9 (NADH:ubiquinone oxidoreductase subunit B9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 349.2), kidney adult (RPKM 234.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufb9 in Genome Data Viewer
    Location:
    15 D1; 15 25.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58805650..58811365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58933801..58939516)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36509 Neighboring gene STARR-seq mESC enhancer starr_38762 Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8590 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8591 Neighboring gene RIKEN cDNA 4930544F09 gene Neighboring gene STARR-positive B cell enhancer ABC_E5481 Neighboring gene STARR-positive B cell enhancer ABC_E7370 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:58879422-58879623 Neighboring gene STARR-positive B cell enhancer ABC_E7371 Neighboring gene STARR-seq mESC enhancer starr_38772 Neighboring gene STARR-seq mESC enhancer starr_38774 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:58921314-58921561 Neighboring gene STARR-seq mESC enhancer starr_38776 Neighboring gene STARR-seq mESC enhancer starr_38777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:58939028-58939233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59006027-59006221 Neighboring gene ribosomal protein L7, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis. Zhu S, et al. J Physiol Biochem, 2022 May. PMID 35122619
    2. Differentiation-dependent repression of c-myc, B22, COX II and COX IV genes in murine erythroleukemia (MEL) cells. Vizirianakis IS, et al. Biochem Pharmacol, 2002 Mar 1. PMID 11911854
    3. Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping. Stylianou IM, et al. Mamm Genome, 2004 Jun. PMID 15181539
    4. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    5. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. Brody MJ, et al. PLoS One, 2012. PMID 23236519, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.
      Title: Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
    Names
    NADH-ubiquinone oxidoreductase B22 subunit
    complex I-B22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364808.1 → NP_001351737.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW060173, BY079922, CK128431
      Conserved Domains (1) summary
      cl05087
      Location:2 → 30
      Complex1_LYR; Complex 1 protein (LYR family)

    2. NM_023172.4 → NP_075661.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1

      See identical proteins and their annotated locations for NP_075661.1

      Status: VALIDATED

      Source sequence(s)
      AK004522, BY079922, CK128431
      Consensus CDS
      CCDS27495.1
      UniProtKB/Swiss-Prot
      Q9CQJ8
      Related
      ENSMUSP00000022980.4, ENSMUST00000022980.5
      Conserved Domains (1) summary
      cd20263
      Location:12 → 88
      Complex1_LYR_NDUFB9_LYRM3; LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58805650..58811365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQJ8.3 GenPept UniProtKB/Swiss-Prot:Q9CQJ8

    Gene LinkOut

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