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    Pabpc4l poly(A) binding protein, cytoplasmic 4-like [ Mus musculus (house mouse) ]

    Gene ID: 241989, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pabpc4lprovided by MGI
    Official Full Name
    poly(A) binding protein, cytoplasmic 4-likeprovided by MGI
    Primary source
    MGI:MGI:3643087
    See related
    Ensembl:ENSMUSG00000090919 AllianceGenome:MGI:3643087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG241989; C330050A14Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in embryo. Orthologous to human PABPC4L (poly(A) binding protein cytoplasmic 4 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pabpc4l in Genome Data Viewer
    Location:
    3 B; 3 20.74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (46395291..46402622, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (46440854..46447989, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26081 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07550 Neighboring gene STARR-seq mESC enhancer starr_07551 Neighboring gene STARR-seq mESC enhancer starr_07553 Neighboring gene STARR-seq mESC enhancer starr_07554 Neighboring gene STARR-seq mESC enhancer starr_07555 Neighboring gene microRNA 6379 Neighboring gene STARR-seq mESC enhancer starr_07556 Neighboring gene STARR-seq mESC enhancer starr_07557 Neighboring gene zinc finger protein, subfamily 1A, 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101479.2 → NP_001094949.1  polyadenylate-binding protein 4-like

      Status: VALIDATED

      Source sequence(s)
      AC101968
      Consensus CDS
      CCDS50904.1
      UniProtKB/TrEMBL
      G5E8X2
      Related
      ENSMUSP00000126224.2, ENSMUST00000166505.7
      Conserved Domains (1) summary
      TIGR01628
      Location:10 → 369
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    2. NM_001416286.1 → NP_001403215.1  polyadenylate-binding protein 4-like

      Status: VALIDATED

      Source sequence(s)
      AC101968
      UniProtKB/TrEMBL
      G5E8X2

    3. NM_001416287.1 → NP_001403216.1  polyadenylate-binding protein 4-like

      Status: VALIDATED

      Source sequence(s)
      AC101968
      UniProtKB/TrEMBL
      G5E8X2

    4. NM_001416288.1 → NP_001403217.1  polyadenylate-binding protein 4-like

      Status: VALIDATED

      Source sequence(s)
      AC101968
      UniProtKB/TrEMBL
      G5E8X2
      Related
      ENSMUSP00000141300.2, ENSMUST00000192793.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      46395291..46402622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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