Dnase2a deoxyribonuclease II alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnase2aprovided by MGI
Official Full Name: deoxyribonuclease II alphaprovided by MGI
Primary source: MGI:MGI:1329019
See related: Ensembl:ENSMUSG00000003812 AllianceGenome:MGI:1329019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnase2
Summary: Enables deoxyribonuclease II activity. Acts upstream of or within DNA catabolic process; enucleate erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Is expressed in liver; olfactory epithelium; and vibrissa. Used to study rheumatoid arthritis. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 17.4), mammary gland adult (RPKM 14.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.31 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85635384..85638332)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84908755..84911703)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration.
Title: Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration.
holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation
Title: Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.
Data show that Klf1 is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a.
Title: Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dnase2a (e-PCR), detects polymorphism
- UniSTS:527316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables deoxyribonuclease II activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonuclease II activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within enucleate erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: deoxyribonuclease-2-alpha

Names: DNase II alpha; acid DNase; lysosomal DNase II

NP_001355224.1

EC 3.1.22.1

NP_001355225.1

EC 3.1.22.1

NP_034192.1

EC 3.1.22.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368295.1 → NP_001355224.1 deoxyribonuclease-2-alpha isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC161765
NM_001368296.1 → NP_001355225.1 deoxyribonuclease-2-alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC161765

Consensus CDS

CCDS90428.1

UniProtKB/TrEMBL

D3Z512

Related

ENSMUSP00000105366.2, ENSMUST00000109744.8
NM_010062.4 → NP_034192.1 deoxyribonuclease-2-alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_034192.1

Status: VALIDATED

Source sequence(s)

AC161765

Consensus CDS

CCDS22484.1

UniProtKB/Swiss-Prot

O55053, P56542

UniProtKB/TrEMBL

Q3UM14

Related

ENSMUSP00000003910.7, ENSMUST00000003910.13

Conserved Domains (2) summary

pfam03265
Location:21 → 346

DNase_II; Deoxyribonuclease II

cl15239
Location:19 → 178

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins