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    ABI1 abl interactor 1 [ Homo sapiens (human) ]

    Gene ID: 10006, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ABI1provided by HGNC
    Official Full Name
    abl interactor 1provided by HGNC
    Primary source
    HGNC:HGNC:11320
    See related
    Ensembl:ENSG00000136754 MIM:603050; AllianceGenome:HGNC:11320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1
    Summary
    This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 23.2), esophagus (RPKM 19.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ABI1 in Genome Data Viewer
    Location:
    10p12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (26746596..26860958, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (26768504..26882882, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (27035525..27149887, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene selenoprotein O like, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:26986797-26987685 Neighboring gene decaprenyl diphosphate synthase subunit 1 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3174 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:27070945-27071686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3175 Neighboring gene small nucleolar RNA SNORA57 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2239 Neighboring gene RNA, U6 small nuclear 946, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3176 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124902398

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. [Abelson interactor 1 (Abi1) in colorectal cancer. From synaptic plasticity to tumor cell migration]. Steinestel K, et al. Pathologe, 2013 Nov. PMID 24196611
    2. [Effect of Abl-interacting protein 1 overexpression upon human gastric cancer cell proliferation in vitro]. Cui MH, et al. Zhonghua Yi Xue Za Zhi, 2009 Dec 1. PMID 20193272
    3. [Increased expression of Abi1 in hepatocellular carcinoma and its correlation with poor prognosis of hepatocellular carcinoma]. Liu SY, et al. Zhonghua Wai Ke Za Zhi, 2009 Nov 15. PMID 20137729
    4. RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis. Li Y, et al. Cell Prolif, 2021 May. PMID 33759281, Free PMC Article
    5. Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms. Dubielecka PM, et al. PLoS One, 2010 May 10. PMID 20479892, Free PMC Article

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adaptor protein Abelson interactor 1 in homeostasis and disease.
      Title: Adaptor protein Abelson interactor 1 in homeostasis and disease.
    2. Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia.
      Title: Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia.
    3. Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers.
      Title: Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers.
    4. ABI1-based expression signature predicts breast cancer metastasis and survival.
      Title: ABI1-based expression signature predicts breast cancer metastasis and survival.
    5. The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer.
      Title: The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer.
    6. Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction.
      Title: Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction.
    7. RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis.
      Title: RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis.
    8. PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
      Title: PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
    9. PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
      Title: PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
    10. Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration.
      Title: Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables cytoskeletal protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin polymerization or depolymerization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in megakaryocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    abl interactor 1
    Names
    Abelson interactor 1
    Abl-interactor protein 1 long
    abl-binding protein 4
    eps8 SH3 domain-binding protein
    interactor protein AblBP4
    nap1 binding protein
    spectrin SH3 domain-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030025.1 RefSeqGene

      Range
      5130..119492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012750.3 → NP_001012768.1  abl interactor 1 isoform b

      See identical proteins and their annotated locations for NP_001012768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB040151, AF006516, AL390961
      Consensus CDS
      CCDS31171.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365310.3, ENST00000376140.4
      Conserved Domains (2) summary
      cd11971
      Location:423 → 481
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    2. NM_001012751.3 → NP_001012769.1  abl interactor 1 isoform c

      See identical proteins and their annotated locations for NP_001012769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB040151, AL390961
      Consensus CDS
      CCDS31170.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365308.3, ENST00000376138.7
      Conserved Domains (2) summary
      cd11971
      Location:394 → 452
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    3. NM_001012752.3 → NP_001012770.1  abl interactor 1 isoform d

      See identical proteins and their annotated locations for NP_001012770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB040151, AL390961, BC024254
      Consensus CDS
      CCDS31169.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365309.2, ENST00000376139.6
      Conserved Domains (2) summary
      cd11971
      Location:418 → 476
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 154
      Abi_HHR; Abl-interactor HHR

    4. NM_001178116.2 → NP_001171587.1  abl interactor 1 isoform e

      See identical proteins and their annotated locations for NP_001171587.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains one alternate exon and lacks a different in-frame coding exon, compared to variant 1. The resulting protein (isoform e) has the same N- and C-termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AK126803, AL390961
      Consensus CDS
      CCDS53501.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000279599.8, ENST00000346832.10
      Conserved Domains (2) summary
      cd11971
      Location:438 → 496
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:110 → 186
      Abi_HHR; Abl-interactor HHR

    5. NM_001178119.2 → NP_001171590.1  abl interactor 1 isoform f

      See identical proteins and their annotated locations for NP_001171590.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame coding exon and uses a different splice site, compared to variant 1. The resulting protein (isoform f) has the same N- and C-termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AB040151, AF006516, AL390961
      Consensus CDS
      CCDS53500.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000352114.4, ENST00000359188.8
      Conserved Domains (2) summary
      cd11971
      Location:422 → 480
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    6. NM_001178120.2 → NP_001171591.1  abl interactor 1 isoform g

      See identical proteins and their annotated locations for NP_001171591.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame coding exons and uses a different splice site, compared to variant 1. The resulting protein (isoform g) has the same N- and C-termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AB040151, AF001628, AL390961
      Consensus CDS
      CCDS53499.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365340.4, ENST00000376170.8
      Conserved Domains (2) summary
      cd11971
      Location:393 → 451
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    7. NM_001178121.2 → NP_001171592.1  abl interactor 1 isoform h

      See identical proteins and their annotated locations for NP_001171592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three alternate in-frame coding exons and uses a different splice site, compared to variant 1. The resulting protein (isoform h) has the same N- and C-termini but is shorter when it is compared to isoform a. This isoform has also been called the 'long' isoform.
      Source sequence(s)
      AB040151, AF260262, AK291823, AL390961
      Consensus CDS
      CCDS53498.1
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365336.1, ENST00000376166.5
      Conserved Domains (2) summary
      cd11971
      Location:388 → 446
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 154
      Abi_HHR; Abl-interactor HHR

    8. NM_001178122.2 → NP_001171593.1  abl interactor 1 isoform i

      See identical proteins and their annotated locations for NP_001171593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform i) has the same N- and C-termini but is shorter when it is compared to isoform a. This isoform has also been called 'variant 41'.
      Source sequence(s)
      AB040151, AL390961, FJ380057
      Consensus CDS
      CCDS73078.1
      UniProtKB/TrEMBL
      B6VEX3, B6VEX5
      Related
      ENSP00000365307.5, ENST00000376137.9
      Conserved Domains (2) summary
      cd11971
      Location:364 → 422
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    9. NM_001178123.2 → NP_001171594.1  abl interactor 1 isoform j

      See identical proteins and their annotated locations for NP_001171594.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks three alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform j) has the same N- and C-termini but is shorter when it is compared to isoform a. This isoform has also been called 'variant 21'.
      Source sequence(s)
      AB040151, AL390961, FJ380058
      Consensus CDS
      CCDS73077.1
      UniProtKB/TrEMBL
      B6VEX4, B6VEX5, F5H1G9
      Related
      ENSP00000439646.2, ENST00000536334.5
      Conserved Domains (2) summary
      cd11971
      Location:335 → 393
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    10. NM_001178124.2 → NP_001171595.1  abl interactor 1 isoform k

      See identical proteins and their annotated locations for NP_001171595.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks three alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform k) has the same N- and C-termini but is shorter when it is compared to isoform a. This isoform has also been called 'variant 72'.
      Source sequence(s)
      AB040151, AL390961, FJ380059
      UniProtKB/TrEMBL
      B6VEX5
      Conserved Domains (2) summary
      cd11971
      Location:330 → 388
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 154
      Abi_HHR; Abl-interactor HHR

    11. NM_001178125.2 → NP_001171596.1  abl interactor 1 isoform l

      See identical proteins and their annotated locations for NP_001171596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks five alternate in-frame coding exons, compared to variant 1. The resulting protein (isoform l) has the same N- and C-termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AK298646, AL390961
      Consensus CDS
      CCDS53497.1
      UniProtKB/TrEMBL
      B6VEX5
      Related
      ENSP00000440101.1, ENST00000490841.7
      Conserved Domains (1) summary
      cd11971
      Location:271 → 329
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1

    12. NM_001348029.2 → NP_001334958.1  abl interactor 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      Q59G41
      Conserved Domains (2) summary
      cd11971
      Location:449 → 507
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    13. NM_001348030.2 → NP_001334959.1  abl interactor 1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      Q59G41
      Conserved Domains (2) summary
      cd11971
      Location:389 → 447
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 154
      Abi_HHR; Abl-interactor HHR

    14. NM_001348031.2 → NP_001334960.1  abl interactor 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      B6VEX5
      Conserved Domains (2) summary
      cd11971
      Location:362 → 420
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    15. NM_001348032.2 → NP_001334961.1  abl interactor 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      Q59G41
      Conserved Domains (2) summary
      cd11971
      Location:421 → 479
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    16. NM_001348033.2 → NP_001334962.1  abl interactor 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      Q59G41
      Conserved Domains (2) summary
      cd11971
      Location:420 → 478
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    17. NM_001348034.2 → NP_001334963.1  abl interactor 1 isoform r

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      UniProtKB/TrEMBL
      B6VEX5
      Conserved Domains (2) summary
      cd11971
      Location:391 → 449
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 169
      Abi_HHR; Abl-interactor HHR

    18. NM_001410909.1 → NP_001397838.1  abl interactor 1 isoform s

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961
      Consensus CDS
      CCDS91224.1
      UniProtKB/TrEMBL
      A0A0A0MRT6, Q59G41
      Related
      ENSP00000365330.1, ENST00000376160.5

    19. NM_005470.4 → NP_005461.2  abl interactor 1 isoform a

      See identical proteins and their annotated locations for NP_005461.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
      Source sequence(s)
      AB040151, AL390961, U87166
      Consensus CDS
      CCDS7150.1
      UniProtKB/Swiss-Prot
      A9Z1Y6, B3KX62, B4DQ58, H7BXI6, O15147, O76049, O95060, Q5T2R3, Q5T2R4, Q5T2R6, Q5T2R7, Q5T2R9, Q5W070, Q5W072, Q8IZP0, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8
      UniProtKB/TrEMBL
      Q59G41
      Related
      ENSP00000365312.2, ENST00000376142.6
      Conserved Domains (2) summary
      cd11971
      Location:450 → 508
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    RNA

    1. NR_145410.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL139404, AL390961

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      26746596..26860958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424407.1 → XP_047280363.1  abl interactor 1 isoform X5

      UniProtKB/TrEMBL
      B6VEX5

    2. XM_047424406.1 → XP_047280362.1  abl interactor 1 isoform X4

      UniProtKB/TrEMBL
      Q59G41

    3. XM_047424404.1 → XP_047280360.1  abl interactor 1 isoform X2

      UniProtKB/TrEMBL
      Q59G41

    4. XM_047424405.1 → XP_047280361.1  abl interactor 1 isoform X3

      UniProtKB/TrEMBL
      Q59G41

    5. XM_005252332.5 → XP_005252389.1  abl interactor 1 isoform X1

      See identical proteins and their annotated locations for XP_005252389.1

      UniProtKB/TrEMBL
      Q59G41
      Conserved Domains (2) summary
      cd11971
      Location:445 → 503
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 154
      Abi_HHR; Abl-interactor HHR

    6. XM_047424409.1 → XP_047280365.1  abl interactor 1 isoform X9

    7. XM_011519289.3 → XP_011517591.1  abl interactor 1 isoform X6

      Conserved Domains (1) summary
      pfam07815
      Location:93 → 169
      Abi_HHR; Abl-interactor HHR

    8. XM_047424408.1 → XP_047280364.1  abl interactor 1 isoform X8

    9. XM_017015459.2 → XP_016870948.1  abl interactor 1 isoform X7

    RNA

    1. XR_007061931.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      26768504..26882882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364459.1 → XP_054220434.1  abl interactor 1 isoform X5

      UniProtKB/TrEMBL
      B6VEX5

    2. XM_054364458.1 → XP_054220433.1  abl interactor 1 isoform X4

      UniProtKB/TrEMBL
      Q59G41

    3. XM_054364456.1 → XP_054220431.1  abl interactor 1 isoform X2

      UniProtKB/TrEMBL
      Q59G41

    4. XM_054364457.1 → XP_054220432.1  abl interactor 1 isoform X3

      UniProtKB/TrEMBL
      Q59G41

    5. XM_054364455.1 → XP_054220430.1  abl interactor 1 isoform X1

      UniProtKB/TrEMBL
      Q59G41

    6. XM_054364460.1 → XP_054220435.1  abl interactor 1 isoform X6

    7. XM_054364463.1 → XP_054220438.1  abl interactor 1 isoform X9

    8. XM_054364462.1 → XP_054220437.1  abl interactor 1 isoform X8

    9. XM_054364461.1 → XP_054220436.1  abl interactor 1 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZP0.4 GenPept UniProtKB/Swiss-Prot:Q8IZP0

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