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    CTBP1-AS CTBP1 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 285463, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CTBP1-ASprovided by HGNC
    Official Full Name
    CTBP1 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:48337
    See related
    Ensembl:ENSG00000280927 AllianceGenome:HGNC:48337
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCAT10
    Expression
    Ubiquitous expression in duodenum (RPKM 7.9), spleen (RPKM 7.5) and 25 other tissues See more
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    Genomic context

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    See CTBP1-AS in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1210120..1218591)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1209315..1217754)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1203908..1212379)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene hornerin-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1143546-1144046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1144047-1144547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21143 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1160925-1161208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1165551-1166266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1166267-1166984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1172226-1172726 Neighboring gene spondin 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1188097-1188808 Neighboring gene uncharacterized LOC100130872 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1190349-1191548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1193431-1193980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21146 Neighboring gene uncharacterized LOC124900164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21149 Neighboring gene C-terminal binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1227715-1228270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1233764-1234264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21151 Neighboring gene CTBP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21152 Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone. Wen M, et al. Mol Med Rep, 2022 Jul. PMID 35656892, Free PMC Article
    2. Androgen receptor coregulator long noncoding RNA CTBP1-AS is associated with polycystic ovary syndrome in Kashmiri women. Nabi M, et al. Endocrine, 2022 Feb. PMID 34611799
    3. Molecular mechanisms of long chain non-coding RNA CTBP1-AS in regulation of invasion and migration of breast cancer cells. Cui HB, et al. J Biol Regul Homeost Agents, 2019 May-Jun,. PMID 31165609
    4. Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study. Liu Z, et al. Reprod Sci, 2015 Jul. PMID 25552498, Free PMC Article
    5. Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. Takayama K, et al. EMBO J, 2013 Jun 12. PMID 23644382, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA CTBP1-AS inhibits TP63-mediated activation of S100A14 during prostate cancer progression.
      Title: LncRNA CTBP1-AS inhibits TP63-mediated activation of S100A14 during prostate cancer progression.
    2. CTBP1AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone.
      Title: CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone.
    3. Androgen receptor coregulator long noncoding RNA CTBP1-AS is associated with polycystic ovary syndrome in Kashmiri women.
      Title: Androgen receptor coregulator long noncoding RNA CTBP1-AS is associated with polycystic ovary syndrome in Kashmiri women.
    4. Overexpressed LncRNA CTBP1-AS promoted breast cancer cell proliferation, invasion as well as migration, inhibited cell apoptosis and accelerated breast cancer development by sponging microRNA-940.
      Title: Molecular mechanisms of long chain non-coding RNA CTBP1-AS in regulation of invasion and migration of breast cancer cells.
    5. CTBP1-AS, a novel androgen receptor regulator, is associated with polycystic ovary syndrome in Chinese women.
      Title: Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • prostate cancer associated transcript 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_104331.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092535, AK092548
      Related
      ENST00000625256.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      1210120..1218591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      1209315..1217754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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