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    ZNF335 zinc finger protein 335 [ Homo sapiens (human) ]

    Gene ID: 63925, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF335provided by HGNC
    Official Full Name
    zinc finger protein 335provided by HGNC
    Primary source
    HGNC:HGNC:15807
    See related
    Ensembl:ENSG00000198026 MIM:610827; AllianceGenome:HGNC:15807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIF1; NIF2; NIF-1; MCPH10
    Summary
    The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.9), skin (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF335 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45948660..45972203, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47684713..47708265, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44577299..44600842, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:44531171-44531366 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene Sharpr-MPRA regulatory region 14031 Neighboring gene Sharpr-MPRA regulatory region 10402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44561248-44561940 Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44562632-44563323 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44563324-44564014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44567204-44567719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44567720-44568234 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:44572602-44573801 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44603922-44604458 Neighboring gene ferritin light chain pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44624055-44624562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44632651-44633302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44633303-44633954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44640983-44641493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12969 Neighboring gene SLC12A5 and MMP9 antisense RNA 1 Neighboring gene matrix metallopeptidase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables histone methyltransferase binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables transcription cis-regulatory region binding  
    Process Evidence Code Pubs
    involved_in brain development  
    involved_in brain development PubMed 
    involved_in brain morphogenesis  
    involved_in cerebral cortex neuron differentiation  
    involved_in epigenetic regulation of gene expression PubMed 
    involved_in in utero embryonic development  
    involved_in neuron projection morphogenesis  
    involved_in positive regulation of lymphocyte proliferation PubMed 
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neurogenesis PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    part_of histone methyltransferase complex PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 335
    Names
    NRC-interacting factor 1
    zinc-finger/leucine-zipper co-transducer NIF1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029772.1 RefSeqGene

      Range
      4992..28535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022095.4NP_071378.1  zinc finger protein 335

      See identical proteins and their annotated locations for NP_071378.1

      Status: REVIEWED

      Source sequence(s)
      AF395833, AL162458, BC041331, BF755826
      Consensus CDS
      CCDS13389.1
      UniProtKB/Swiss-Prot
      B4DLG7, Q548D0, Q9H4Z2, Q9H684
      Related
      ENSP00000325326.2, ENST00000322927.3
      Conserved Domains (6) summary
      PRK04654
      Location:795911
      PRK04654; sec-independent translocase; Provisional
      sd00017
      Location:10491069
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:529545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:590612
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:10891114
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10751097
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45948660..45972203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260504.5XP_005260561.1  zinc finger protein 335 isoform X2

      Conserved Domains (6) summary
      PRK04654
      Location:794910
      PRK04654; sec-independent translocase; Provisional
      sd00017
      Location:10481068
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:528544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:589611
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:10881113
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:10741096
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. XM_047440363.1XP_047296319.1  zinc finger protein 335 isoform X1

      UniProtKB/Swiss-Prot
      B4DLG7, Q548D0, Q9H4Z2, Q9H684
    3. XM_011528979.4XP_011527281.1  zinc finger protein 335 isoform X3

      Conserved Domains (4) summary
      sd00017
      Location:564584
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:529545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:590612
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:577600
      zf-H2C2_2; Zinc-finger double domain
    4. XM_047440364.1XP_047296320.1  zinc finger protein 335 isoform X4

    5. XM_047440365.1XP_047296321.1  zinc finger protein 335 isoform X5

    RNA

    1. XR_936602.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47684713..47708265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323816.1XP_054179791.1  zinc finger protein 335 isoform X2

    2. XM_054323815.1XP_054179790.1  zinc finger protein 335 isoform X1

    3. XM_054323817.1XP_054179792.1  zinc finger protein 335 isoform X3

    4. XM_054323818.1XP_054179793.1  zinc finger protein 335 isoform X4

    5. XM_054323819.1XP_054179794.1  zinc finger protein 335 isoform X5

    RNA

    1. XR_008485290.1 RNA Sequence

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