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    BAIAP2L2 BAR/IMD domain containing adaptor protein 2 like 2 [ Homo sapiens (human) ]

    Gene ID: 80115, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BAIAP2L2provided by HGNC
    Official Full Name
    BAR/IMD domain containing adaptor protein 2 like 2provided by HGNC
    Primary source
    HGNC:HGNC:26203
    See related
    Ensembl:ENSG00000128298 MIM:617536; AllianceGenome:HGNC:26203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in duodenum (RPKM 28.1), small intestine (RPKM 24.8) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BAIAP2L2 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38084900..38110967, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38546488..38574157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38480907..38506691, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38452863-38453488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38453489-38454112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38470967-38471468 Neighboring gene protein interacting with PRKCA 1 Neighboring gene uncharacterized LOC105373027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38476553-38477334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38479675-38480456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene solute carrier family 16 member 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38510521-38511423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38518609-38519118 Neighboring gene phospholipase A2 group VI Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38538756-38539256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38559728-38560228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38560229-38560729 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38561911 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38570189 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38572440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18996 Neighboring gene Sharpr-MPRA regulatory region 6169 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38580917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13709 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38600595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13710 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38603571 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607237 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607534 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38608227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38609813-38610394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13712 Neighboring gene MAF bZIP transcription factor F Neighboring gene transmembrane protein 184B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis. Wei H, et al. Sci Rep, 2023 May 29. PMID 37248248, Free PMC Article
    2. BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways. Song Y, et al. Genes Genomics, 2021 Apr. PMID 33646530
    3. BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer. Xu L, et al. Oncol Rep, 2019 Feb. PMID 30483805
    4. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways. Liu J, et al. Biomed Pharmacother, 2020 Sep. PMID 32570120
    5. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Pykäläinen A, et al. Nat Struct Mol Biol, 2011 Jul 10. PMID 21743456, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.
      Title: BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.
    2. HNF1beta-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
      Title: HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
    3. BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways.
      Title: BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways.
    4. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/beta-catenin signaling pathways.
      Title: BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
    5. these findings revealed BAIAP2L2 as a novel biomarker and potential therapeutic target for lung cancer
      Title: BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22582

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of clathrin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BAR/IMD domain-containing adapter protein 2-like 2
    Names
    BAI1 associated protein 2 like 2
    BAI1-associated protein 2-like protein 2
    brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    pinkbar
    planar intestinal- and kidney-specific BAR domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033059.2 RefSeqGene

      Range
      4986..30770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_025045.6 → NP_079321.3  BAR/IMD domain-containing adapter protein 2-like 2

      See identical proteins and their annotated locations for NP_079321.3

      Status: REVIEWED

      Source sequence(s)
      AL022322, AW007403, AY358164, KF457452
      Consensus CDS
      CCDS43018.1
      UniProtKB/Swiss-Prot
      B0QYE2, Q6UXY1, Q96BG7
      Related
      ENSP00000371085.3, ENST00000381669.8
      Conserved Domains (2) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:331 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38084900..38110967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005261751.5 → XP_005261808.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X6

      See identical proteins and their annotated locations for XP_005261808.1

      UniProtKB/Swiss-Prot
      B0QYE2, Q6UXY1, Q96BG7
      Conserved Domains (2) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:331 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

    2. XM_011530379.4 → XP_011528681.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6UXY1
      Conserved Domains (3) summary
      cd07644
      Location:6 → 220
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cd11914
      Location:331 → 385
      SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cl41728
      Location:499 → 514
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    3. XM_011530384.3 → XP_011528686.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X5

      Conserved Domains (2) summary
      cl12013
      Location:63 → 190
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:301 → 355
      SH3; Src Homology 3 domain superfamily

    4. XM_011530381.3 → XP_011528683.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X3

      See identical proteins and their annotated locations for XP_011528683.1

      Conserved Domains (2) summary
      cd07644
      Location:1 → 201
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    5. XM_011530383.3 → XP_011528685.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X4

      Conserved Domains (2) summary
      cl12013
      Location:69 → 196
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:307 → 361
      SH3; Src Homology 3 domain superfamily

    6. XM_011530382.3 → XP_011528684.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X3

      See identical proteins and their annotated locations for XP_011528684.1

      Conserved Domains (2) summary
      cd07644
      Location:1 → 201
      I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    7. XM_011530380.4 → XP_011528682.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X2

      Conserved Domains (2) summary
      cl12013
      Location:75 → 202
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:313 → 367
      SH3; Src Homology 3 domain superfamily

    8. XM_011530388.3 → XP_011528690.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X8

      Conserved Domains (1) summary
      cl17036
      Location:124 → 178
      SH3; Src Homology 3 domain superfamily

    9. XM_011530387.4 → XP_011528689.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X7

      See identical proteins and their annotated locations for XP_011528689.1

      UniProtKB/TrEMBL
      A0A804CBC2
      Conserved Domains (1) summary
      cl17036
      Location:136 → 190
      SH3; Src Homology 3 domain superfamily

    10. XM_011530386.3 → XP_011528688.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X7

      See identical proteins and their annotated locations for XP_011528688.1

      UniProtKB/TrEMBL
      A0A804CBC2
      Conserved Domains (1) summary
      cl17036
      Location:136 → 190
      SH3; Src Homology 3 domain superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38546488..38574157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325926.1 → XP_054181901.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X6

      UniProtKB/Swiss-Prot
      B0QYE2, Q6UXY1, Q96BG7

    2. XM_054325920.1 → XP_054181895.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X1

    3. XM_054325925.1 → XP_054181900.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X5

    4. XM_054325922.1 → XP_054181897.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X3

    5. XM_054325924.1 → XP_054181899.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X4

    6. XM_054325923.1 → XP_054181898.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X3

    7. XM_054325921.1 → XP_054181896.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X2

    8. XM_054325929.1 → XP_054181904.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X8

    9. XM_054325928.1 → XP_054181903.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X7

      UniProtKB/TrEMBL
      A0A804CBC2

    10. XM_054325927.1 → XP_054181902.1  BAR/IMD domain-containing adapter protein 2-like 2 isoform X7

      UniProtKB/TrEMBL
      A0A804CBC2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXY1.1 GenPept UniProtKB/Swiss-Prot:Q6UXY1

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