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    SLC16A6 solute carrier family 16 member 6 [ Homo sapiens (human) ]

    Gene ID: 9120, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC16A6provided by HGNC
    Official Full Name
    solute carrier family 16 member 6provided by HGNC
    Primary source
    HGNC:HGNC:10927
    See related
    Ensembl:ENSG00000108932 MIM:603880; AllianceGenome:HGNC:10927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT6; MCT7
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in esophagus (RPKM 4.8), appendix (RPKM 3.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A6 in Genome Data Viewer
    Location:
    17q24.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68267026..68291479, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69143596..69168075, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66263167..66287268, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene arylsulfatase G Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409262-66409920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409921-66410577 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene microRNA 635 Neighboring gene WD repeat domain, phosphoinositide interacting 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Murakami Y, et al. Drug Metab Dispos, 2005 Dec. PMID 16174808
    2. Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival. Dai W, et al. Mol Carcinog, 2020 Jun. PMID 32232919, Free PMC Article
    3. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. Higuchi K, et al. J Biol Chem, 2022 Apr. PMID 35257743, Free PMC Article
    4. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article
    5. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter.
      Title: Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter.
    2. Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.
      Title: Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.
    3. MCT6 is involved in the disposition of various drugs, including bumetanide.
      Title: Functional characterization of human monocarboxylate transporter 6 (SLC16A5).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of solute carrier family 16, member 6 (SLC16A6) in Vif-expression T cells PubMed
    capsid gag Depletion of the SLC16A6 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables taurine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in taurine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 7
    Names
    breast cancer protein BCY5
    monocarboxylate transporter 6
    solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174166.2 → NP_001167637.1  monocarboxylate transporter 7

      See identical proteins and their annotated locations for NP_001167637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC005332, BC064832, U79745
      Consensus CDS
      CCDS11675.1
      UniProtKB/Swiss-Prot
      O15403, Q6P1X3
      UniProtKB/TrEMBL
      A8K302
      Related
      ENSP00000319991.4, ENST00000327268.8
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    2. NM_004694.5 → NP_004685.2  monocarboxylate transporter 7

      See identical proteins and their annotated locations for NP_004685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC005332, BC064832
      Consensus CDS
      CCDS11675.1
      UniProtKB/Swiss-Prot
      O15403, Q6P1X3
      UniProtKB/TrEMBL
      A8K302
      Related
      ENSP00000462985.1, ENST00000580666.6
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      68267026..68291479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451021.2 → XP_024306789.2  monocarboxylate transporter 7 isoform X1

      UniProtKB/TrEMBL
      A8K302

    2. XM_011525461.4 → XP_011523763.1  monocarboxylate transporter 7 isoform X2

      See identical proteins and their annotated locations for XP_011523763.1

      UniProtKB/Swiss-Prot
      O15403, Q6P1X3
      UniProtKB/TrEMBL
      A8K302
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    3. XM_047437020.1 → XP_047292976.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/Swiss-Prot
      O15403, Q6P1X3
      UniProtKB/TrEMBL
      A8K302

    4. XM_017025292.3 → XP_016880781.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/Swiss-Prot
      O15403, Q6P1X3
      UniProtKB/TrEMBL
      A8K302
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      69143596..69168075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317736.1 → XP_054173711.1  monocarboxylate transporter 7 isoform X1

      UniProtKB/TrEMBL
      A8K302

    2. XM_054317737.1 → XP_054173712.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/TrEMBL
      A8K302

    3. XM_054317738.1 → XP_054173713.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/TrEMBL
      A8K302

    4. XM_054317739.1 → XP_054173714.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/TrEMBL
      A8K302
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15403.2 GenPept UniProtKB/Swiss-Prot:O15403

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