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    Sdsl serine dehydratase-like [ Mus musculus (house mouse) ]

    Gene ID: 257635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdslprovided by MGI
    Official Full Name
    serine dehydratase-likeprovided by MGI
    Primary source
    MGI:MGI:2182607
    See related
    Ensembl:ENSMUSG00000029596 AllianceGenome:MGI:2182607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TDH; SDH1; SDS-RS1; 4432411H13Rik
    Summary
    Predicted to enable several functions, including ammonia-lyase activity; glutamate racemase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and notochord. Orthologous to human SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 41.3), duodenum adult (RPKM 15.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sdsl in Genome Data Viewer
    Location:
    5 F; 5 60.62 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120596258..120610890, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120458193..120472825, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox 5, antisense 1 Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2173 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene. Edgar AJ. BMC Genomics, 2005 Mar 9. PMID 15757516, Free PMC Article
    2. Positional cloning of the murine flavivirus resistance gene. Perelygin AA, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12080145, Free PMC Article
    3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate racemase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    serine dehydratase-like
    Names
    L-serine deaminase
    L-serine dehydratase/L-threonine deaminase
    L-threonine dehydratase
    SDH
    glutamate racemase
    serine dehydratase related sequence 1
    NP_001371183.1
    NP_598663.2
    XP_011246504.2
    XP_036021034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384254.1 → NP_001371183.1  serine dehydratase-like

      Status: VALIDATED

      Source sequence(s)
      AC129553
      UniProtKB/Swiss-Prot
      Q8R238, Q8VI05
      Related
      ENSMUSP00000031594.7, ENSMUST00000031594.13
      Conserved Domains (1) summary
      cd06448
      Location:17 → 326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    2. NM_133902.3 → NP_598663.2  serine dehydratase-like

      See identical proteins and their annotated locations for NP_598663.2

      Status: VALIDATED

      Source sequence(s)
      AC129553
      Consensus CDS
      CCDS19618.1
      UniProtKB/Swiss-Prot
      Q8R238, Q8VI05
      Related
      ENSMUSP00000058198.8, ENSMUST00000052258.14
      Conserved Domains (1) summary
      cd06448
      Location:17 → 326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120596258..120610890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248202.2 → XP_011246504.2  serine dehydratase-like isoform X1

      UniProtKB/Swiss-Prot
      Q8R238, Q8VI05
      Conserved Domains (1) summary
      cd06448
      Location:17 → 326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    2. XM_036165141.1 → XP_036021034.1  serine dehydratase-like isoform X2

      Conserved Domains (1) summary
      cl00342
      Location:20 → 274
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R238.1 GenPept UniProtKB/Swiss-Prot:Q8R238

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