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Links from GEO Profiles

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    St13 suppression of tumorigenicity 13 [ Mus musculus (house mouse) ]

    Gene ID: 70356, updated on 13-Jan-2025

    Summary

    Official Symbol
    St13provided by MGI
    Official Full Name
    suppression of tumorigenicity 13provided by MGI
    Primary source
    MGI:MGI:1917606
    See related
    Ensembl:ENSMUSG00000022403 AllianceGenome:MGI:1917606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIP; HOP; p48; SNC6; HSPABP; HSPABP1; PRO0786; 1110007I03Rik; 3110002K08Rik
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; dATP binding activity; and unfolded protein binding activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 66.5), CNS E11.5 (RPKM 53.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See St13 in Genome Data Viewer
    Location:
    15 E1; 15 38.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81247869..81284278, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81365044..81399694, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52179 Neighboring gene solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 Neighboring gene STARR-positive B cell enhancer mm9_chr15:81163002-81163302 Neighboring gene STARR-seq mESC enhancer starr_39251 Neighboring gene STARR-positive B cell enhancer ABC_E2445 Neighboring gene STARR-positive B cell enhancer ABC_E7396 Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    enables Hsp70 protein binding  
    enables dATP binding  
    enables identical protein binding  
    enables protein dimerization activity  
    enables protein domain specific binding  
    enables protein-containing complex binding  
    enables protein-folding chaperone binding  
    enables unfolded protein binding  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    hsc70-interacting protein
    Names
    Hsp70 interacting protein
    protein ST13 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418649.1NP_001405578.1  hsc70-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/Swiss-Prot
      Q4FJT4, Q99L47
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    2. NM_001418650.1NP_001405579.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    3. NM_001418651.1NP_001405580.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    4. NM_001418652.1NP_001405581.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    5. NM_001418653.1NP_001405582.1  hsc70-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    6. NM_001418654.1NP_001405583.1  hsc70-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109153
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
    7. NM_133726.3NP_598487.1  hsc70-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_598487.1

      Status: VALIDATED

      Source sequence(s)
      AC109153
      Consensus CDS
      CCDS27667.1
      UniProtKB/Swiss-Prot
      Q4FJT4, Q99L47
      UniProtKB/TrEMBL
      Q3U3N7, Q3U8D2, Q3U9V1
      Related
      ENSMUSP00000130195.2, ENSMUST00000172107.8
      Conserved Domains (5) summary
      smart00727
      Location:321360
      STI1; Heat shock chaperonin-binding motif
      cd14438
      Location:343
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:113141
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:147179
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:112178
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81247869..81284278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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