Mipep mitochondrial intermediate peptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mipepprovided by RGD
Official Full Name: mitochondrial intermediate peptidaseprovided by RGD
Primary source: RGD:621680
See related: EnsemblRapid:ENSRNOG00000013876 AllianceGenome:RGD:621680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables endopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 125.1), Kidney (RPKM 118.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (39102301..39227915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (34926198..35051722)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (41084180..41192621)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AU048566 (e-PCR)
- UniSTS:145016

BE117302 (e-PCR)
- UniSTS:261796

D15Rat86 (e-PCR), detects polymorphism
- UniSTS:226743

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial intermediate peptidase

Names: MIP

NP_112314.2

EC 3.4.24.59

XP_008769001.2

EC 3.4.24.59

XP_038949613.1

EC 3.4.24.59

XP_063130763.1

EC 3.4.24.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031052.2 → NP_112314.2 mitochondrial intermediate peptidase precursor

Status: VALIDATED

Source sequence(s)

CR459947, FM061883, FM065705, FM100741, FM117087, FN806671, JAXUCZ010000015

UniProtKB/Swiss-Prot

Q01992

Related

ENSRNOP00000110169.1, ENSRNOT00000162084.1

Conserved Domains (2) summary

cd06457
Location:62 → 695

M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)

COG0339
Location:71 → 691

Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

39102301..39227915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093685.2 → XP_038949613.1 mitochondrial intermediate peptidase isoform X1

UniProtKB/Swiss-Prot

Q01992

UniProtKB/TrEMBL

A0A0G2K4T8

Related

ENSRNOP00000073167.2, ENSRNOT00000085785.3

Conserved Domains (1) summary

cd06457
Location:62 → 678

M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
XM_008770779.4 → XP_008769001.2 mitochondrial intermediate peptidase isoform X2

UniProtKB/Swiss-Prot

Q01992

Related

ENSRNOP00000104331.1, ENSRNOT00000163454.1
XM_063274693.1 → XP_063130763.1 mitochondrial intermediate peptidase isoform X3