Tsg101 tumor susceptibility 101 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tsg101provided by RGD
Official Full Name: tumor susceptibility 101provided by RGD
Primary source: RGD:3909
See related: EnsemblRapid:ENSRNOG00000013381 AllianceGenome:RGD:3909
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rw
Summary: Enables nuclear receptor coactivator activity. Involved in endosome to lysosome transport and protein monoubiquitination. Located in endosome membrane. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 204.6), Kidney (RPKM 202.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106549035..106578859, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (97412689..97442589, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (102941151..102971017, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mechanical stress upregulates TSG101 in podocytes.
Title: Upregulation of Tumor Susceptibility Gene 101 (TSG101) by mechanical stress in podocytes.
Hrs and Tsg101 as crucial regulators of trafficking of Cx43 to lysosomes.
Title: Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.
These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability.
Title: GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
TSG101 activates androgen receptor-induced transcription by transient stabilization of the monoubiquitinated state
Title: TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat267 (e-PCR), detects polymorphism
- UniSTS:227086

AU047244 (e-PCR)
- UniSTS:110700

AI255943 (e-PCR)
- UniSTS:179575

RH130601 (e-PCR)
- UniSTS:213885

AW140530 (e-PCR)
- UniSTS:260588

BI276330 (e-PCR)
- UniSTS:249849

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables virion binding	IEA Inferred from Electronic Annotation more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in extracellular transport	IEA Inferred from Electronic Annotation more info
involved_in extracellular transport	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral budding via host ESCRT complex	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral budding via host ESCRT complex	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular exosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular exosome assembly	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral budding	IEA Inferred from Electronic Annotation more info
involved_in viral budding	ISO Inferred from Sequence Orthology more info
involved_in viral budding	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral release from host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT I complex	ISO Inferred from Sequence Orthology more info
part_of ESCRT I complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor susceptibility gene 101 protein

Names: ESCRT-I complex subunit TSG101; Tumor supressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181628.2 → NP_853659.2 tumor susceptibility gene 101 protein

See identical proteins and their annotated locations for NP_853659.2

Status: PROVISIONAL

Source sequence(s)

BC070951

UniProtKB/Swiss-Prot

Q6IRE4, Q7TSE5

UniProtKB/TrEMBL

A0A8I5ZSM6, A6JBD7

Related

ENSRNOP00000018194.7, ENSRNOT00000018194.8

Conserved Domains (4) summary

PHA03369
Location:147 → 324

PHA03369; capsid maturational protease; Provisional

TIGR02168
Location:242 → 384

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05743
Location:21 → 139

UEV; UEV domain

pfam09454
Location:317 → 376

Vps23_core; Vps23 core domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

106549035..106578859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284274.1 → XP_063140344.1 tumor susceptibility gene 101 protein isoform X1
XM_008759341.4 → XP_008757563.1 tumor susceptibility gene 101 protein isoform X2

UniProtKB/TrEMBL

A0A8L2Q9C5

Conserved Domains (3) summary

TIGR02168
Location:189 → 331

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05743
Location:21 → 139

UEV; UEV domain

pfam09454
Location:264 → 323

Vps23_core; Vps23 core domain
XM_039105117.2 → XP_038961045.1 tumor susceptibility gene 101 protein isoform X3

UniProtKB/TrEMBL

A0A8I5ZSM6

Conserved Domains (4) summary

PHA03369
Location:53 → 230

PHA03369; capsid maturational protease; Provisional

TIGR02168
Location:148 → 290

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09454
Location:223 → 282

Vps23_core; Vps23 core domain

cl00154
Location:1 → 45

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
XM_039105126.2 → XP_038961054.1 tumor susceptibility gene 101 protein isoform X4

Conserved Domains (3) summary

PHA03369
Location:17 → 181

PHA03369; capsid maturational protease; Provisional

TIGR02168
Location:112 → 254

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09454
Location:187 → 246

Vps23_core; Vps23 core domain
XM_063284275.1 → XP_063140345.1 tumor susceptibility gene 101 protein isoform X3

UniProtKB/TrEMBL

A0A8I5ZSM6