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    Ube2j1 ubiquitin-conjugating enzyme E2, J1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2j1provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2, J1provided by RGD
    Primary source
    RGD:1305067
    See related
    EnsemblRapid:ENSRNOG00000007434 AllianceGenome:RGD:1305067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein N-linked glycosylation via asparagine. Predicted to act upstream of or within regulation of macrophage cytokine production; regulation of tumor necrosis factor production; and spermatid development. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 242.0), Spleen (RPKM 213.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2j1 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52218807..52237805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47422476..47441476)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48274387..48292699)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding D Neighboring gene uncharacterized LOC108350947 Neighboring gene ribonuclease P/MRP subunit p38, pseudogene 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 2 Neighboring gene uncharacterized LOC120102852

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. Koenig PA, et al. J Biol Chem, 2014 Dec 12. PMID 25320092, Free PMC Article
    2. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production. Menon MB, et al. Biochem J, 2013 Dec 1. PMID 24020373
    3. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Burr ML, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245296, Free PMC Article
    4. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Imai Y, et al. Cell, 2001 Jun 29. PMID 11439185
    5. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. Sato T, et al. Mol Cell, 2012 Jul 13. PMID 22607976

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 J1
    Names
    ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
    NP_001100112.2
    XP_008761834.1
    XP_038965356.1
    XP_038965357.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106642.2 → NP_001100112.2  ubiquitin-conjugating enzyme E2 J1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MKH4, A0A8I6A9S4
      Related
      ENSRNOP00000090289.2, ENSRNOT00000110935.2
      Conserved Domains (1) summary
      cd00195
      Location:12 → 119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52218807..52237805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109428.2 → XP_038965356.1  ubiquitin-conjugating enzyme E2 J1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9S4
      Related
      ENSRNOP00000068517.3, ENSRNOT00000075992.4
      Conserved Domains (1) summary
      cd00195
      Location:1 → 104
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. XM_039109429.2 → XP_038965357.1  ubiquitin-conjugating enzyme E2 J1 isoform X2

      UniProtKB/TrEMBL
      A6IIK6
      Related
      ENSRNOP00000112829.1, ENSRNOT00000156136.1
      Conserved Domains (1) summary
      cd00195
      Location:12 → 119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_008763612.3 → XP_008761834.1  ubiquitin-conjugating enzyme E2 J1 isoform X3

      See identical proteins and their annotated locations for XP_008761834.1

      UniProtKB/TrEMBL
      A0A8I6A9S4, A6IIK5
      Conserved Domains (1) summary
      cd00195
      Location:12 → 119
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version

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