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    Alg3 ALG3, alpha-1,3- mannosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg3provided by RGD
    Official Full Name
    ALG3, alpha-1,3- mannosyltransferaseprovided by RGD
    Primary source
    RGD:1306004
    See related
    EnsemblRapid:ENSRNOG00000001712 AllianceGenome:RGD:1306004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 44.0), Adrenal (RPKM 43.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg3 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93804859..93810403)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80300487..80306014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83985484..83991706)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene uncharacterized LOC102551647 Neighboring gene ATP binding cassette subfamily F member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. Körner C, et al. EMBO J, 1999 Dec 1. PMID 10581255, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
    Names
    alpha-1,3-mannosyltransferase ALG3
    asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog
    dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
    NP_001135835.1
    XP_006248620.1
    XP_063126400.1
    XP_063126401.1
    XP_063126402.1
    XP_063126403.1
    XP_063126404.1
    XP_063126405.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142363.1 → NP_001135835.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

      Status: VALIDATED

      Source sequence(s)
      BC088475, CO401508, FM075565
      UniProtKB/TrEMBL
      A6JSA4
      Conserved Domains (1) summary
      pfam05208
      Location:49 → 406
      ALG3; ALG3 protein

    RNA

    1. NR_024535.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC088475, FM075565

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93804859..93810403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270332.1 → XP_063126402.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X4

      UniProtKB/TrEMBL
      Q5M7T0

    2. XM_063270333.1 → XP_063126403.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X5

      UniProtKB/TrEMBL
      A0A8I6GKZ1

    3. XM_006248558.4 → XP_006248620.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X2

      UniProtKB/TrEMBL
      M0R7D2
      Related
      ENSRNOP00000095000.2, ENSRNOT00000119074.2
      Conserved Domains (1) summary
      pfam05208
      Location:49 → 309
      ALG3; ALG3 protein

    4. XM_063270330.1 → XP_063126400.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      A6JSA4
      Related
      ENSRNOP00000002331.8, ENSRNOT00000002331.10

    5. XM_063270331.1 → XP_063126401.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X3

      UniProtKB/TrEMBL
      A6JSA4

    6. XM_063270334.1 → XP_063126404.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X6

    7. XM_063270335.1 → XP_063126405.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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