Cradd CASP2 and RIPK1 domain containing adaptor with death domain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Craddprovided by RGD
Official Full Name: CASP2 and RIPK1 domain containing adaptor with death domainprovided by RGD
Primary source: RGD:1311010
See related: EnsemblRapid:ENSRNOG00000008507 AllianceGenome:RGD:1311010
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RAIDD
Summary: Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of cysteine-type endopeptidase activity involved in apoptotic process; and cellular response to mechanical stimulus. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 63.0), Thymus (RPKM 48.9) and 9 other tissues See more
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Genomic context

Location:: 7q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (31827131..31839796, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (29940240..29952907, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (36395665..36408588, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aggregation is important for its death-promoting effects and may play a role in neuronal apoptosis
Title: RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Rat149 (e-PCR), detects polymorphism
- UniSTS:228104

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables death domain binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: death domain-containing protein CRADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108085.1 → NP_001101555.1 death domain-containing protein CRADD

See identical proteins and their annotated locations for NP_001101555.1

Status: PROVISIONAL

Source sequence(s)

CH473960

UniProtKB/TrEMBL

A6IG29, D3ZB14

Related

ENSRNOP00000104895.1, ENSRNOT00000153556.1

Conserved Domains (1) summary

cd08327
Location:1 → 94

CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain