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    Mfsd10 major facilitator superfamily domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfsd10provided by RGD
    Official Full Name
    major facilitator superfamily domain containing 10provided by RGD
    Primary source
    RGD:1311900
    See related
    EnsemblRapid:ENSRNOG00000012534 AllianceGenome:RGD:1311900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tetran; RGD1311900
    Summary
    Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within sodium-independent organic anion transport. Predicted to be located in cytoplasmic vesicle membrane and nuclear inner membrane. Predicted to be active in brush border membrane. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 66.4), Thymus (RPKM 63.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd10 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80327961..80331984)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76103762..76107385)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81362594..81366208)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481857 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene NOP14 nucleolar protein Neighboring gene adducin 1 Neighboring gene uncharacterized LOC120096505 Neighboring gene SH3-domain binding protein 2 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and function of TETRAN, a new type of membrane transporter. Ushijima H, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18638446
    2. Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, et al. Nucleus, 2019 Dec. PMID 31142202, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sodium-independent organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 10
    Names
    tetracycline transporter-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191680.2 → NP_001178609.1  major facilitator superfamily domain-containing protein 10

      See identical proteins and their annotated locations for NP_001178609.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZZQ6, D3ZD83
      Related
      ENSRNOP00000095916.1, ENSRNOT00000104363.2
      Conserved Domains (1) summary
      cd17389
      Location:52 → 434
      MFS_MFSD10; Major facilitator superfamily domain-containing protein 10

    2. NM_001412512.1 → NP_001399441.1  major facilitator superfamily domain-containing protein 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZZQ6, D3ZD83

    3. NM_001412513.1 → NP_001399442.1  major facilitator superfamily domain-containing protein 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZZQ6, D3ZD83

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      80327961..80331984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091974.2 → XP_038947902.1  major facilitator superfamily domain-containing protein 10 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:52 → 307
      MFS; Major Facilitator Superfamily

    2. XM_006251246.5 → XP_006251308.1  major facilitator superfamily domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_006251308.1

      UniProtKB/TrEMBL
      A0A8I5ZZQ6, D3ZD83
      Conserved Domains (1) summary
      cd17389
      Location:52 → 434
      MFS_MFSD10; Major facilitator superfamily domain-containing protein 10

    RNA

    1. XR_005492957.2 RNA Sequence

      Related
      ENSRNOT00000017386.7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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