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    Ctdspl2 CTD small phosphatase like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctdspl2provided by RGD
    Official Full Name
    CTD small phosphatase like 2provided by RGD
    Primary source
    RGD:1309219
    See related
    EnsemblRapid:ENSRNOG00000022141 AllianceGenome:RGD:1309219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309219
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Predicted to be located in nucleoplasm. Orthologous to human CTDSPL2 (CTD small phosphatase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 255.9), Spleen (RPKM 194.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctdspl2 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129365709..129424232)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108915263..108970620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113906803..113957289)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 5 Neighboring gene barrier-to-autointegration factor-like Neighboring gene prohibitin 2, pseudogene 2 Neighboring gene golgi membrane protein 2 Neighboring gene uncharacterized LOC134486142 Neighboring gene eukaryotic translation initiation factor 3, subunit J Neighboring gene SPG11 vesicle trafficking associated, spatacsin Neighboring gene PAT1 homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation. Wani S, et al. J Biochem, 2016 Aug. PMID 26920047
    2. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. Zhao Y, et al. J Biol Chem, 2014 Sep 19. PMID 25100727, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CTD small phosphatase-like protein 2
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
    CTDSP-like 2
    NP_001014070.3
    NP_001396503.1
    XP_038960896.2
    XP_063139806.1
    XP_063139807.1
    XP_063139808.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014048.5 → NP_001014070.3  CTD small phosphatase-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5XIK8
      UniProtKB/TrEMBL
      A0A8I6AJK5, A6HPR2

    2. NM_001409574.3 → NP_001396503.1  CTD small phosphatase-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5XIK8
      UniProtKB/TrEMBL
      A0A8I6AJK5, A6HPR2
      Related
      ENSRNOP00000033786.8, ENSRNOT00000037168.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      129365709..129424232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283736.1 → XP_063139806.1  CTD small phosphatase-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJK5

    2. XM_063283737.1 → XP_063139807.1  CTD small phosphatase-like protein 2 isoform X2

    3. XM_063283738.1 → XP_063139808.1  CTD small phosphatase-like protein 2 isoform X3

    4. XM_039104968.2 → XP_038960896.2  CTD small phosphatase-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJK5

    RNA

    1. XR_010064623.1 RNA Sequence

    2. XR_010064625.1 RNA Sequence

    3. XR_010064624.1 RNA Sequence

    4. XR_010064620.1 RNA Sequence

    5. XR_010064621.1 RNA Sequence

    6. XR_010064626.1 RNA Sequence

    7. XR_010064622.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIK8.1 GenPept UniProtKB/Swiss-Prot:Q5XIK8

    Gene LinkOut

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