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    Atp11b ATPase phospholipid transporting 11B (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp11bprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 11B (putative)provided by RGD
    Primary source
    RGD:1561719
    See related
    EnsemblRapid:ENSRNOG00000052116 AllianceGenome:RGD:1561719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in early endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 302.1), Spleen (RPKM 231.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp11b in Genome Data Viewer
    Location:
    2q25
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120513535..120619249)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (118585348..118691076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (122337757..122445090)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor associated protein like 2, pseudogene 3 Neighboring gene RNA, U6 small nuclear 1158 Neighboring gene uncharacterized LOC134485899 Neighboring gene defective in cullin neddylation 1 domain containing 1 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model. Quick S, et al. Acta Neuropathol, 2022 Aug. PMID 35635573, Free PMC Article
    2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
      Title: Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IF
    Names
    ATPase, class VI, type 11B
    probable phospholipid-transporting ATPase IF
    NP_001413956.1
    XP_038959541.1
    XP_038959542.1
    XP_038959543.1
    XP_038959544.1
    XP_063138130.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427027.1 → NP_001413956.1  phospholipid-transporting ATPase IF

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A6I4, A0A8I6AJL0
      Related
      ENSRNOP00000099142.1, ENSRNOT00000168974.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      120513535..120619249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103615.2 → XP_038959543.1  phospholipid-transporting ATPase IF isoform X3

      UniProtKB/TrEMBL
      A0A8I6A6I4
      Related
      ENSRNOP00000093840.2, ENSRNOT00000117945.2
      Conserved Domains (2) summary
      cd02073
      Location:41 → 978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      cl40732
      Location:959 → 1085
      AA_permease_2; Amino acid permease

    2. XM_039103614.2 → XP_038959542.1  phospholipid-transporting ATPase IF isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6I4
      Related
      ENSRNOP00000088435.2, ENSRNOT00000116170.2
      Conserved Domains (2) summary
      cd02073
      Location:41 → 978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      cl40732
      Location:959 → 1085
      AA_permease_2; Amino acid permease

    3. XM_039103613.2 → XP_038959541.1  phospholipid-transporting ATPase IF isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQT8
      Related
      ENSRNOP00000081047.2, ENSRNOT00000108850.2
      Conserved Domains (2) summary
      cd02073
      Location:41 → 978
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      cl40732
      Location:959 → 1085
      AA_permease_2; Amino acid permease

    4. XM_063282060.1 → XP_063138130.1  phospholipid-transporting ATPase IF isoform X4

      UniProtKB/TrEMBL
      A0A8I6ATU1

    5. XM_039103616.1 → XP_038959544.1  phospholipid-transporting ATPase IF isoform X5

      Conserved Domains (2) summary
      cl21460
      Location:1 → 616
      HAD_like; Haloacid Dehalogenase-like Hydrolases
      cl40732
      Location:597 → 723
      AA_permease_2; Amino acid permease
    Nucleotide Protein Strain
    Heading Accession and Version

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