Trmt12 tRNA methyltransferase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trmt12provided by RGD
Official Full Name: tRNA methyltransferase 12provided by RGD
Primary source: RGD:1307127
See related: EnsemblRapid:ENSRNOG00000008978 AllianceGenome:RGD:1307127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307127
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (92307319..92308945)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (90417846..90419472)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (98748547..98750173)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA wybutosine-synthesizing protein 2 homolog

Names: alpha-amino-alpha-carboxypropyl transferase TYW2; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2

NP_001116448.1

EC 2.5.1.114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122976.2 → NP_001116448.1 tRNA wybutosine-synthesizing protein 2 homolog

See identical proteins and their annotated locations for NP_001116448.1

Status: PROVISIONAL

Source sequence(s)

BC097456

UniProtKB/Swiss-Prot

Q4V8B8, Q6AXV3

UniProtKB/TrEMBL

A6HRK8

Related

ENSRNOP00000011874.5, ENSRNOT00000011876.7

Conserved Domains (2) summary

cd02440
Location:228 → 326

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

COG2520
Location:12 → 432

Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]