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    Vwa3a von Willebrand factor A domain containing 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vwa3aprovided by RGD
    Official Full Name
    von Willebrand factor A domain containing 3Aprovided by RGD
    Primary source
    RGD:1311670
    See related
    EnsemblRapid:ENSRNOG00000025110 AllianceGenome:RGD:1311670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311670
    Summary
    Orthologous to human VWA3A (von Willebrand factor A domain containing 3A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 47.3), Testes (RPKM 34.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwa3a in Genome Data Viewer
    Location:
    1q36
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (184725106..184786884)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175293782..175355588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (190679722..190742444)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene modulator of smoothened Neighboring gene large ribosomal subunit protein uL10-like Neighboring gene uncharacterized LOC102555900 Neighboring gene uncharacterized LOC120099921 Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene transfer RNA leucine (anticodon UAG) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC156760

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079885.1 → NP_001073354.1  von Willebrand factor A domain-containing protein 3A isoform 2

      See identical proteins and their annotated locations for NP_001073354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. The resulting isoform (2) is much shorter than isoform 1 at the C-terminus.
      Source sequence(s)
      BC128762
      UniProtKB/Swiss-Prot
      A1A5Q7
      UniProtKB/TrEMBL
      A0A8I5ZM94
      Related
      ENSRNOP00000079157.1, ENSRNOT00000102809.2
      Conserved Domains (1) summary
      cl00057
      Location:143 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001198653.1 → NP_001185582.1  von Willebrand factor A domain-containing protein 3A isoform 1

      See identical proteins and their annotated locations for NP_001185582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I8S2, F1M1K0
      Conserved Domains (2) summary
      cd00198
      Location:923 → 1073
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl00057
      Location:143 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      184725106..184786884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230159.5 → XP_006230221.1  von Willebrand factor A domain-containing protein 3A isoform X9

      UniProtKB/TrEMBL
      F1M1K0
      Related
      ENSRNOP00000032210.7, ENSRNOT00000036175.7
      Conserved Domains (2) summary
      cd00198
      Location:930 → 1080
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl00057
      Location:143 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_063285910.1 → XP_063141980.1  von Willebrand factor A domain-containing protein 3A isoform X1

      UniProtKB/TrEMBL
      F1M1K0

    3. XM_063285917.1 → XP_063141987.1  von Willebrand factor A domain-containing protein 3A isoform X3

      UniProtKB/TrEMBL
      A6I8S3

    4. XM_039107079.2 → XP_038963007.1  von Willebrand factor A domain-containing protein 3A isoform X5

      UniProtKB/TrEMBL
      A6I8S3
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_039107074.2 → XP_038963002.1  von Willebrand factor A domain-containing protein 3A isoform X4

      UniProtKB/TrEMBL
      A6I8S3
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    6. XM_039107082.2 → XP_038963010.1  von Willebrand factor A domain-containing protein 3A isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZM94
      Conserved Domains (1) summary
      cl00057
      Location:142 → 297
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    7. XM_063285923.1 → XP_063141993.1  von Willebrand factor A domain-containing protein 3A isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM94
      Related
      ENSRNOP00000107280.1, ENSRNOT00000166387.1

    8. XM_063285926.1 → XP_063141996.1  von Willebrand factor A domain-containing protein 3A isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZM94

    9. XM_063285913.1 → XP_063141983.1  von Willebrand factor A domain-containing protein 3A isoform X2

      UniProtKB/TrEMBL
      F1M1K0

    RNA

    1. XR_010065632.1 RNA Sequence

    2. XR_005503151.2 RNA Sequence

    3. XR_005503154.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A5Q7.1 GenPept UniProtKB/Swiss-Prot:A1A5Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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