Etv4 ETS variant transcription factor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etv4provided by RGD
Official Full Name: ETS variant transcription factor 4provided by RGD
Primary source: RGD:1306524
See related: EnsemblRapid:ENSRNOG00000020792 AllianceGenome:RGD:1306524
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pea3
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of keratinocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Predicted to be located in chromosome and nucleolus. Predicted to be active in nucleus. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 38.1), Brain (RPKM 20.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87206977..87222202, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86706749..86721974, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89685058..89700300, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
Title: Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
Title: Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
these data establish Etv4 and Etv5 as essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation
Title: Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.
Newly identified gene rat PEA3 may play an important role in kidney development and differentiation.
Title: Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3.
The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.
Title: Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.
expression of PEA3 in mammary tumors leads to up-regulation of Muc4/SMC transcription, the gene product of which may contribute to the metastatic potential of mammary tumors.
Title: PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.

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General gene information

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Markers

Etv4 (e-PCR), detects polymorphism
- UniSTS:547916

X63190 (e-PCR)
- UniSTS:163517

RH142884 (e-PCR)
- UniSTS:232131

RH132517 (e-PCR)
- UniSTS:215800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ETS translocation variant 4

Names: ets variant gene 4 (E1A enhancer binding protein, E1AF); polyomavirus enhancer activator-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108299.1 → NP_001101769.1 ETS translocation variant 4

See identical proteins and their annotated locations for NP_001101769.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HJF1, B5DF72, E9PTJ2

Conserved Domains (2) summary

smart00413
Location:343 → 426

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 341

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

87206977..87222202 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768086.4 → XP_008766308.1 ETS translocation variant 4 isoform X3

UniProtKB/TrEMBL

B5DF72

Related

ENSRNOP00000028213.5, ENSRNOT00000028213.8

Conserved Domains (2) summary

smart00413
Location:384 → 467

ETS; erythroblast transformation specific domain

pfam04621
Location:53 → 382

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006247369.5 → XP_006247431.1 ETS translocation variant 4 isoform X2

UniProtKB/TrEMBL

B5DF72

Conserved Domains (2) summary

smart00413
Location:390 → 473

ETS; erythroblast transformation specific domain

pfam04621
Location:53 → 388

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006247372.5 → XP_006247434.1 ETS translocation variant 4 isoform X4

See identical proteins and their annotated locations for XP_006247434.1

UniProtKB/TrEMBL

B5DF72

Conserved Domains (2) summary

smart00413
Location:344 → 427

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 342

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_063269443.1 → XP_063125513.1 ETS translocation variant 4 isoform X1

UniProtKB/TrEMBL

B5DF72
XM_039086407.2 → XP_038942335.1 ETS translocation variant 4 isoform X5

UniProtKB/TrEMBL

A6HJF1, B5DF72, E9PTJ2

Conserved Domains (2) summary

smart00413
Location:343 → 426

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 341

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006247371.5 → XP_006247433.1 ETS translocation variant 4 isoform X4

See identical proteins and their annotated locations for XP_006247433.1

UniProtKB/TrEMBL

B5DF72

Related

ENSRNOP00000070185.3, ENSRNOT00000084311.3

Conserved Domains (2) summary

smart00413
Location:344 → 427

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 342

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006247370.5 → XP_006247432.1 ETS translocation variant 4 isoform X4

See identical proteins and their annotated locations for XP_006247432.1

UniProtKB/TrEMBL

B5DF72

Conserved Domains (2) summary

smart00413
Location:344 → 427

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 342

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_017597400.3 → XP_017452889.2 ETS translocation variant 4 isoform X1

UniProtKB/TrEMBL

B5DF72
XM_063269444.1 → XP_063125514.1 ETS translocation variant 4 isoform X7
XM_039086410.2 → XP_038942338.1 ETS translocation variant 4 isoform X6

UniProtKB/TrEMBL

A0A8I6AQD4, A6HJF2

Conserved Domains (2) summary

smart00413
Location:301 → 384

ETS; erythroblast transformation specific domain

pfam04621
Location:26 → 299

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain