Mal mal, T-cell differentiation protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Malprovided by RGD
Official Full Name: mal, T-cell differentiation proteinprovided by RGD
Primary source: RGD:3037
See related: EnsemblRapid:ENSRNOG00000015445 AllianceGenome:RGD:3037
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MALGENE
Summary: A structural constituent of myelin sheath. Involved in myelination. Located in Schmidt-Lanterman incisure. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human MAL (mal, T cell differentiation protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 930.8), Kidney (RPKM 923.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (135317664..135341423, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114864378..114888136, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (120209647..120233655, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL.
Title: The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.
Significant upregulation of MAL in the retinal ganglion cells after optic nerve crush was found.
Title: The expression changes of myelin and lymphocyte protein (MAL) following optic nerve crush in adult rats retinal ganglion cells.
this is the first description of MAL expression changes in gray matter after spinal cord injury. Our results prompted that MAL might participate in CNS pathophysiology after SCI.
Title: Upregulation of myelin and lymphocyte protein (MAL) after traumatic spinal cord injury in rats.
MAL, but not MAL2, self-associates with higher-order cholesterol-dependent complexes with apical proteins and promotes the formation of detergent-resistant membranes that recruit apical proteins.
Title: MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins.
Data suggest that the involvement of MAL/VIP17 in the activation and surface expression of NKCC2 could play an important role in the regulated absorption of Na+ and Cl- in the kidney.
Title: MAL/VIP17, a new player in the regulation of NKCC2 in the kidney.
Loss of MAL expression is aasociated with precancerous lesions of the esophagus
Title: Loss of MAL expression in precancerous lesions of the esophagus.

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General gene information

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Markers

RH134160 (e-PCR)
- UniSTS:217442

RH142312 (e-PCR)
- UniSTS:231559

RH134822 (e-PCR)
- UniSTS:218100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of myelin sheath	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of myelin sheath	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination	IDA Inferred from Direct Assay more info	PubMed
involved_in myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to paranode region of axon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in hinge region between urothelial plaques of apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myelin and lymphocyte protein

Names: 17 kDa myelin vesicular protein; MVP17; NS 3; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein, T-cell differentiation protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.