Axin2 axin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Axin2provided by RGD
Official Full Name: axin 2provided by RGD
Primary source: RGD:69259
See related: EnsemblRapid:ENSRNOG00000055010 AllianceGenome:RGD:69259
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: axil; axin-2
Summary: Enables beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; negative regulation of Wnt signaling pathway; and positive regulation of fat cell differentiation. Part of protein-containing complex. Used to study Parkinson's disease. Biomarker of dilated cardiomyopathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 134.5), Thymus (RPKM 88.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (94393379..94426579)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (93893830..93927042)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (97212483..97238824)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Axin-2 knockdown promote mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/beta-catenin signaling in rat model of Parkinson's disease.
Title: Axin-2 knockdown promote mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/β-catenin signaling in rat model of Parkinson's disease.
Results suggest that Axin2 plays a key role in adipocyte and osteoblastic differentiation by controlling beta-catenin expression.
Title: Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells.
Axin2 expression in the E19 gubernaculum confirms canonical Wnt pathway activation. Its absence in the core of flutamide-treated gubernacula indicates Wnt down-regulation
Title: Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Axin2 (e-PCR), detects polymorphism
- UniSTS:526850

AU027845 (e-PCR)
- UniSTS:112908

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte differentiation involved in endochondral bone morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in intramembranous ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intramembranous ossification	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of DNA repeat elements	IEA Inferred from Electronic Annotation more info
involved_in maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of centromeric sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of centromeric sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of centromeric sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of chondrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chondrocyte development	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mismatch repair	IEA Inferred from Electronic Annotation more info
involved_in regulation of mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: axin-2

Names: axin-like protein; axis inhibition protein 2; conductin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024355.1 → NP_077331.1 axin-2

See identical proteins and their annotated locations for NP_077331.1

Status: PROVISIONAL

Source sequence(s)

AF017757

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

94393379..94426579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085705.2 → XP_038941633.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain
XM_039085702.2 → XP_038941630.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain
XM_039085700.2 → XP_038941628.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Related

ENSRNOP00000073088.2, ENSRNOT00000088599.3

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain
XM_039085701.2 → XP_038941629.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain
XM_039085704.2 → XP_038941632.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain
XM_039085703.2 → XP_038941631.1 axin-2 isoform X1

UniProtKB/Swiss-Prot

O70240

UniProtKB/TrEMBL

A0A8I6AE31

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:756 → 838

DAX; Domain present in Dishevelled and axin

cd11582
Location:12 → 73

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:433 → 468

Axin_b-cat_bind; Axin beta-catenin binding domain