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    Sulf2 sulfatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sulf2provided by RGD
    Official Full Name
    sulfatase 2provided by RGD
    Primary source
    RGD:1305078
    See related
    EnsemblRapid:ENSRNOG00000006052 AllianceGenome:RGD:1305078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and glycosaminoglycan binding activity. Involved in positive regulation of endothelin production. Predicted to be located in extracellular region. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 147.3), Heart (RPKM 132.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sulf2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (175241322..175323808, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154822079..154904566, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (162791349..162872984, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909912 Neighboring gene nuclear receptor coactivator 3 Neighboring gene uncharacterized LOC120101930 Neighboring gene uncharacterized LOC134486206 Neighboring gene uncharacterized LOC120101786 Neighboring gene uncharacterized LOC108350523 Neighboring gene uncharacterized LOC134486477

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. Nagamine S, et al. Brain Res Dev Brain Res, 2005 Oct 6. PMID 16139897
    2. Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases. Nagamine S, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19900405
    3. Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Zaman G, et al. Histochem Cell Biol, 2016 Jan. PMID 26464246
    4. Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats. Kim HY, et al. Cytokine, 2019 Feb. PMID 30470661
    5. Functional consequences of the subdomain organization of the sulfs. Tang R, et al. J Biol Chem, 2009 Aug 7. PMID 19520866, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that Sulf2 is an up-regulatory factor in the additive action of CXCL8 via the AT1 R pathway on Ang II-induced ET-1 expression in vascular smooth muscle cells under hypertension environment.
      Title: Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
    2. Examination of epiphyseal growth plates revealed differential, inverse patterns of SULF1 and SULF2 expressions, with the former enriched in quiescent and the latter in hypertrophic chondrocyte zones.
      Title: Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.
    3. It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
      Title: Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.
    4. the cleavage of rat Sulf2 occurs at two arginine residues, 543 and 570, in the hydrophilic domain.
      Title: Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in esophagus smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glomerular basement membrane development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innervation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-2
    Names
    sulfatase FP2
    NP_001030099.1
    XP_006235658.1
    XP_038961065.1
    XP_063139951.1
    XP_063139952.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034927.1 → NP_001030099.1  extracellular sulfatase Sulf-2 precursor

      See identical proteins and their annotated locations for NP_001030099.1

      Status: PROVISIONAL

      Source sequence(s)
      AY742216
      UniProtKB/TrEMBL
      A6JXG7, B2GUU3, F7F080, Q3L472
      Related
      ENSRNOP00000008478.4, ENSRNOT00000008478.6
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 666
      DUF3740; Sulfatase protein
      cl23718
      Location:754 → 803
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      175241322..175323808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235596.5 → XP_006235658.1  extracellular sulfatase Sulf-2 isoform X1

      See identical proteins and their annotated locations for XP_006235658.1

      UniProtKB/TrEMBL
      A6JXG7, B2GUU3, F7F080, Q3L472
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 666
      DUF3740; Sulfatase protein
      cl23718
      Location:754 → 803
      ALP_like; alkaline phosphatases and sulfatases

    2. XM_063283881.1 → XP_063139951.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/TrEMBL
      A6JXG7, B2GUU3, F7F080, Q3L472
      Related
      ENSRNOP00000087036.2, ENSRNOT00000095721.2

    3. XM_039105137.2 → XP_038961065.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/TrEMBL
      A6JXG7, B2GUU3, F7F080, Q3L472
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 666
      DUF3740; Sulfatase protein
      cl23718
      Location:754 → 803
      ALP_like; alkaline phosphatases and sulfatases

    4. XM_063283882.1 → XP_063139952.1  extracellular sulfatase Sulf-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCI2, B2GUU3
      Related
      ENSRNOP00000085144.1, ENSRNOT00000106312.2
    Nucleotide Protein Strain
    Heading Accession and Version

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