Ckmt1 creatine kinase, mitochondrial 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ckmt1provided by RGD
Official Full Name: creatine kinase, mitochondrial 1provided by RGD
Primary source: RGD:61976
See related: EnsemblRapid:ENSRNOG00000014573 AllianceGenome:RGD:61976
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ckmt1b
Summary: Enables creatine kinase activity and identical protein binding activity. Involved in several processes, including cerebellum development; digestive tract development; and skeletal muscle tissue development. Located in mitochondrial inner-outer membrane contact site and perikaryon. Biomarker of status epilepticus. Orthologous to several human genes including CKMT1B (creatine kinase, mitochondrial 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 720.2), Kidney (RPKM 262.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128783408..128789485)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (108329859..108335760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (113318559..113324459)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum.
Title: Effects of β-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
The role of ubiquitous mitochondrial creatine kinase (uMtCK) reaction in regulation of mitochondrial respiration was studied in purified preparations of rat brain synaptosomes and mitochondria.
Title: Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase.
In chronic epilepsy rats, uMtCK immunoreactivity is markedly reduced in hippocampal CA1-3 pyramidal cells and hilar neurons due to massive neuronal loss.
Title: Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_3102-3103:991936731:1 (e-PCR)
- UniSTS:230988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables creatine kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner-outer membrane contact site	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: creatine kinase U-type, mitochondrial

Names: U-MtCK; acidic-type mitochondrial creatine kinase; creatine kinase, mitochondrial 1, ubiquitous; creatine kinase, mitochondrial 1B; mia-CK; ubiquitous mitochondrial creatine kinase

NP_001012756.1

EC 2.7.3.2

XP_006234892.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012738.1 → NP_001012756.1 creatine kinase U-type, mitochondrial precursor

See identical proteins and their annotated locations for NP_001012756.1

Status: PROVISIONAL

Source sequence(s)

BC091335

UniProtKB/Swiss-Prot

P25809

UniProtKB/TrEMBL

Q5BJT9

Related

ENSRNOP00000044253.3, ENSRNOT00000051354.5

Conserved Domains (1) summary

cd00716
Location:50 → 407

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

128783408..128789485

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234830.5 → XP_006234892.1 creatine kinase U-type, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006234892.1

UniProtKB/Swiss-Prot

P25809

UniProtKB/TrEMBL

Q5BJT9

Conserved Domains (1) summary

cd00716
Location:50 → 407

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes