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    Ifnlr1 interferon, lambda receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifnlr1provided by RGD
    Official Full Name
    interferon, lambda receptor 1provided by RGD
    Primary source
    RGD:1562689
    See related
    EnsemblRapid:ENSRNOG00000033984 AllianceGenome:RGD:1562689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Il28ra; RGD1562689
    Summary
    Predicted to enable cytokine receptor activity. Predicted to be involved in several processes, including mucosal immune response; positive regulation of cellular respiration; and regulation of defense response to virus by host. Predicted to act upstream of or within defense response to virus. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in plasma membrane. Orthologous to human IFNLR1 (interferon lambda receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 21.6), Heart (RPKM 18.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ifnlr1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153203597..153225911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147919547..147942328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154037243..154058862)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700029M20 gene like Neighboring gene uncharacterized LOC134479040 Neighboring gene interleukin 22 receptor subunit alpha 1 Neighboring gene myomesin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IFN-lambda determines the intestinal epithelial antiviral host defense. Pott J, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518880, Free PMC Article
    2. IL-28, IL-29 and their class II cytokine receptor IL-28R. Sheppard P, et al. Nat Immunol, 2003 Jan. PMID 12469119
    3. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. Ank N, et al. J Immunol, 2008 Feb 15. PMID 18250457
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mucosal immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of interleukin-28 receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon lambda receptor 1
    Names
    interleukin 28 receptor alpha
    interleukin-28 receptor subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191868.2 → NP_001178797.1  interferon lambda receptor 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZB58
      Related
      ENSRNOP00000048303.4, ENSRNOT00000049459.7
      Conserved Domains (1) summary
      pfam01108
      Location:20 → 109
      Tissue_fac; Tissue factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153203597..153225911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288069.1 → XP_063144139.1  interferon lambda receptor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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