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    Pitpnc1 phosphatidylinositol transfer protein, cytoplasmic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pitpnc1provided by RGD
    Official Full Name
    phosphatidylinositol transfer protein, cytoplasmic 1provided by RGD
    Primary source
    RGD:1597047
    See related
    EnsemblRapid:ENSRNOG00000069160 AllianceGenome:RGD:1597047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipid binding activity and phospholipid transfer activity. Predicted to be involved in phospholipid transport and signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 128.2), Lung (RPKM 87.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pitpnc1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92663260..92928616, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (92163558..92428971, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95429879..95697734, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein 11 Neighboring gene actin, beta, pseudogene 10 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene male-enhanced antigen 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene ribosomal protein L17, pseudogene 16 Neighboring gene ribosomal protein S23, pseudogene 9 Neighboring gene proteasome 26S subunit, non-ATPase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. Garner K, et al. J Biol Chem, 2012 Sep 14. PMID 22822086, Free PMC Article
    2. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. Fullwood Y, et al. J Biol Chem, 1999 Oct 29. PMID 10531358

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables phosphatidylcholine transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic phosphatidylinositol transfer protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427418.1 → NP_001414347.1  cytoplasmic phosphatidylinositol transfer protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AKK7
      Related
      ENSRNOP00000084076.2, ENSRNOT00000116944.2

    2. NM_001427419.1 → NP_001414348.1  cytoplasmic phosphatidylinositol transfer protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZSD8
      Related
      ENSRNOP00000080117.1, ENSRNOT00000110826.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      92663260..92928616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087430.2 → XP_038943358.1  cytoplasmic phosphatidylinositol transfer protein 1 isoform X1

      Conserved Domains (2) summary
      cd08890
      Location:2 → 250
      SRPBCC_PITPNC1_like; Lipid-binding SRPBCC domain of mammalian PITPNC1,and related proteins (Class IIB PITPs)
      NF033839
      Location:292 → 414
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    Nucleotide Protein Strain
    Heading Accession and Version

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