Timm10b translocase of inner mitochondrial membrane 10B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Timm10bprovided by RGD
Official Full Name: translocase of inner mitochondrial membrane 10Bprovided by RGD
Primary source: RGD:71097
See related: EnsemblRapid:ENSRNOG00000050846 AllianceGenome:RGD:71097
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fxc1; Tim9b; tim10b
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 130.9), Adrenal (RPKM 130.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169392355..169395201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (159980525..159983371)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170471265..170474111)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex	ISO Inferred from Sequence Orthology more info
part_of TIM22 mitochondrial import inner membrane insertion complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
part_of mitochondrial intermembrane space protein transporter complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial intermembrane space protein transporter complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit Tim10 B

Names: fracture callus 1; fracture callus protein 1; fractured callus expressed transcript 1; mitochondrial import inner membrane translocase subunit Tim9 B; translocase of inner mitochondrial membrane 10 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389232.1 → NP_001376161.1 mitochondrial import inner membrane translocase subunit Tim10 B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O88471, Q9R1B1

UniProtKB/TrEMBL

A6I7L1, F1LTU8

Conserved Domains (1) summary

pfam02953
Location:3 → 64

zf-Tim10_DDP; Tim10/DDP family zinc finger
NM_053371.3 → NP_445823.1 mitochondrial import inner membrane translocase subunit Tim10 B

See identical proteins and their annotated locations for NP_445823.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O88471, Q9R1B1

UniProtKB/TrEMBL

A6I7L1, F1LTU8

Related

ENSRNOP00000110273.1, ENSRNOT00000165846.1

Conserved Domains (1) summary

pfam02953
Location:3 → 64

zf-Tim10_DDP; Tim10/DDP family zinc finger